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EGLU: Wikis


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Systematic (IUPAC) name
(2S)-2-amino-2-ethylpentanedioic acid
CAS number  ?
ATC code  ?
PubChem 5311079
Chemical data
Formula C 7H13NO4  
Mol. mass 175.182 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

(2S)-α-Ethylglutamic acid (EGLU) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterisation and study of this receptor subfamily.[1][2][3][4][5][6][7]


  1. ^ Jane DE, Thomas NK, Tse HW, Watkins JC. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology. 1996;35(8):1029-35. PMID 9121605
  2. ^ Huang L, Rowan MJ, Anwyl R. Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro. European Journal of Pharmacology. 1999 Feb 5;366(2-3):151-8. PMID 10082195
  3. ^ Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, Rossi F, Maione S. Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception. Neuropharmacology. 2001 Mar;40(3):319-26. PMID 11166324
  4. ^ Iserhot C, Gebhardt C, Schmitz D, Heinemann U. Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat. Brain Research. 2004 Nov 19;1027(1-2):151-60. PMID 15494166
  5. ^ Cahusac PM, Wan H. Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo. Neuroscience. 2007 Apr 25;146(1):202-12. PMID 17346894
  6. ^ Kim WY, Vezina P, Kim JH. Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment. Behavioural Brain Research. 2008 Aug 5;191(1):62-6. PMID 18433894
  7. ^ Altinbilek B, Manahan-Vaughan D. A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory. Neuroscience. 2009 Jan 12;158(1):149-58. PMID 18722513


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