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EGR2: Wikis


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Early growth response 2 (Krox-20 homolog, Drosophila)

PDB rendering based on 1a1i.
Available structures
1a1i, 1a1j, 1a1k, 1a1l, 1aay, 1jk1, 1jk2, 1p47, 1zaa
Symbols EGR2; CMT1D; CMT4E; DKFZp686J1957; FLJ14547; KROX20
External IDs OMIM129010 MGI95296 HomoloGene20123 GeneCards: EGR2 Gene
RNA expression pattern
PBB GE EGR2 205249 at tn.png
More reference expression data
Species Human Mouse
Entrez 1959 13654
Ensembl ENSG00000122877 ENSMUSG00000037868
UniProt P11161 Q3U207
RefSeq (mRNA) NM_000399 NM_010118
RefSeq (protein) NP_000390 NP_034248
Location (UCSC) Chr 10:
64.24 - 64.25 Mb
Chr 10:
66.93 - 66.94 Mb
PubMed search [1] [2]

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.

The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.[1]


Further reading

  • Rangnekar VM, Aplin AC, Sukhatme VP (1990). "The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein.". Nucleic Acids Res. 18 (9): 2749–57. doi:10.1093/nar/18.9.2749. PMID 2111009.  
  • Chavrier P, Janssen-Timmen U, Mattéi MG, et al. (1989). "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos.". Mol. Cell. Biol. 9 (2): 787–97. PMID 2496302.  
  • Joseph LJ, Le Beau MM, Jamieson GA, et al. (1988). "Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7164–8. doi:10.1073/pnas.85.19.7164. PMID 3140236.  
  • Topilko P, Schneider-Maunoury S, Levi G, et al. (1994). "Krox-20 controls myelination in the peripheral nervous system.". Nature 371 (6500): 796–9. doi:10.1038/371796a0. PMID 7935840.  
  • Sham MH, Vesque C, Nonchev S, et al. (1993). "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation.". Cell 72 (2): 183–96. doi:10.1016/0092-8674(93)90659-E. PMID 8093858.  
  • Levi G, Topilko P, Schneider-Maunoury S, et al. (1996). "Role of Krox-20 in endochondral bone formation.". Ann. N. Y. Acad. Sci. 785: 288–91. PMID 8702157.  
  • Warner LE, Mancias P, Butler IJ, et al. (1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies.". Nat. Genet. 18 (4): 382–4. doi:10.1038/ng0498-382. PMID 9537424.  
  • Warner LE, Svaren J, Milbrandt J, Lupski JR (1999). "Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.". Hum. Mol. Genet. 8 (7): 1245–51. doi:10.1093/hmg/8.7.1245. PMID 10369870.  
  • Timmerman V, De Jonghe P, Ceuterick C, et al. (1999). "Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype.". Neurology 52 (9): 1827–32. PMID 10371530.  
  • Bellone E, Di Maria E, Soriani S, et al. (1999). "A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease.". Hum. Mutat. 14 (4): 353–4. doi:10.1002/(SICI)1098-1004(199910)14:4<353::AID-HUMU17>3.0.CO;2-4. PMID 10502832.  
  • Pareyson D, Taroni F, Botti S, et al. (2000). "Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation.". Neurology 54 (8): 1696–8. PMID 10762521.  
  • Gambardella L, Schneider-Maunoury S, Voiculescu O, et al. (2000). "Pattern of expression of the transcription factor Krox-20 in mouse hair follicle.". Mech. Dev. 96 (2): 215–8. doi:10.1016/S0925-4773(00)00398-1. PMID 10960786.  
  • Yoshihara T, Kanda F, Yamamoto M, et al. (2001). "A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1.". J. Neurol. Sci. 184 (2): 149–53. doi:10.1016/S0022-510X(00)00504-9. PMID 11239949.  
  • Boerkoel CF, Takashima H, Bacino CA, et al. (2002). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy.". Neurogenetics 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566.  
  • Yang Y, Dong B, Mittelstadt PR, et al. (2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.". J. Biol. Chem. 277 (22): 19482–7. doi:10.1074/jbc.M201687200. PMID 11909874.  
  • Vandenberghe N, Upadhyaya M, Gatignol A, et al. (2003). "Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies.". J. Med. Genet. 39 (12): e81. doi:10.1136/jmg.39.12.e81. PMID 12471219.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Musso M, Balestra P, Taroni F, et al. (2003). "Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter.". Neurobiol. Dis. 12 (1): 89–95. doi:10.1016/S0969-9961(02)00018-9. PMID 12609493.  
  • Unoki M, Nakamura Y (2003). "EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK.". Oncogene 22 (14): 2172–85. doi:10.1038/sj.onc.1206222. PMID 12687019.  
  • Numakura C, Shirahata E, Yamashita S, et al. (2003). "Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1.". J. Neurol. Sci. 210 (1-2): 61–4. doi:10.1016/S0022-510X(03)00028-5. PMID 12736090.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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