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EHF (gene): Wikis


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From Wikipedia, the free encyclopedia

Ets homologous factor
Symbols EHF; ESE3; ESEJ
External IDs OMIM605439 MGI1270840 HomoloGene7301 GeneCards: EHF Gene
RNA expression pattern
PBB GE EHF 219850 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26298 13661
Ensembl ENSG00000135373 ENSMUSG00000012350
UniProt Q9NZC4 O70273
RefSeq (mRNA) NM_012153 NM_007914
RefSeq (protein) NP_036285 NP_031940
Location (UCSC) Chr 11:
34.6 - 34.64 Mb
Chr 2:
103.06 - 103.1 Mb
PubMed search [1] [2]

ETS homologous factor is a protein that in humans is encoded by the EHF gene.[1][2]

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.[2]


  1. ^ Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun 264 (1): 119-26. doi:10.1006/bbrc.1999.1493. PMID 10527851.  
  2. ^ a b "Entrez Gene: EHF ets homologous factor".  

Further reading

  • Fujikawa M, Katagiri T, Tugores A, et al. (2007). "ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence.". Cancer Sci. 98 (9): 1468–75. doi:10.1111/j.1349-7006.2007.00543.x. PMID 17627613.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  • Park C, Lee I, Kang WK (2007). "Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis.". Mol. Cancer Ther. 5 (12): 3191–6. doi:10.1158/1535-7163.MCT-06-0570. PMID 17172423.  
  • Lim JH, Cho JY, Park YB, et al. (2006). "ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites.". Biochem. Biophys. Res. Commun. 350 (3): 736–41. doi:10.1016/j.bbrc.2006.09.102. PMID 17027647.  
  • Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.  
  • Appel S, Bringmann A, Grünebach F, et al. (2006). "Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs.". Blood 107 (8): 3265–70. doi:10.1182/blood-2005-06-2480. PMID 16380452.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Silverman ES, Baron RM, Palmer LJ, et al. (2003). "Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung.". Am. J. Respir. Cell Mol. Biol. 27 (6): 697–704. PMID 12444029.  
  • Tugores A, Le J, Sorokina I, et al. (2001). "The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades.". J. Biol. Chem. 276 (23): 20397–406. doi:10.1074/jbc.M010930200. PMID 11259407.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Kas K, Finger E, Grall F, et al. (2000). "ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.". J. Biol. Chem. 275 (4): 2986–98. doi:10.1074/jbc.275.4.2986. PMID 10644770.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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