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E74-like factor 4 (ets domain transcription factor)
Symbols ELF4; ELFR; MEF
External IDs MGI1928377 HomoloGene31036 GeneCards: ELF4 Gene
RNA expression pattern
PBB GE ELF4 31845 at tn.png
PBB GE ELF4 203490 at tn.png
More reference expression data
Species Human Mouse
Entrez 2000 56501
Ensembl ENSG00000102034 ENSMUSG00000031103
UniProt Q99607 Q32MF0
RefSeq (mRNA) NM_001421 XM_989007
RefSeq (protein) NP_001412 XP_994101
Location (UCSC) Chr X:
129.03 - 129.07 Mb
Chr X:
44.66 - 44.67 Mb
PubMed search [1] [2]

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.[1][2]


  1. ^ Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S (Dec 1996). "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties". Oncogene 13 (8): 1721-9. PMID 8895518.  
  2. ^ "Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor)".  

Further reading

  • Liu Y, Hedvat CV, Mao S, et al. (2006). "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.". Mol. Cell. Biol. 26 (8): 3114–23. doi:10.1128/MCB.26.8.3114-3123.2006. PMID 16581786.  
  • Moore SD, Offor O, Ferry JA, et al. (2007). "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).". Leuk. Res. 30 (8): 1037–42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lu Z, Kim KA, Suico MA, et al. (2004). "MEF up-regulates human beta-defensin 2 expression in epithelial cells.". FEBS Lett. 561 (1-3): 117–21. doi:10.1016/S0014-5793(04)00138-3. PMID 15013761.  
  • Suico MA, Yoshida H, Seki Y, et al. (2004). "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.". J. Biol. Chem. 279 (18): 19091–8. doi:10.1074/jbc.M312439200. PMID 14976184.  
  • Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.  
  • Hedvat CV, Yao J, Sokolic RA, Nimer SD (2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.". J. Biol. Chem. 279 (8): 6395–400. doi:10.1074/jbc.M307524200. PMID 14625302.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Suico MA, Koyanagi T, Ise S, et al. (2002). "Functional dissection of the ETS transcription factor MEF.". Biochim. Biophys. Acta 1577 (1): 113–20. PMID 12151102.  
  • Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.". Mol. Cell. Biol. 19 (5): 3635–44. PMID 10207087.  
  • Aryee DN, Petermann R, Kos K, et al. (1998). "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.". Gene 210 (1): 71–8. doi:10.1016/S0378-1119(98)00022-5. PMID 9524226.  

External links



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