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ELK1, member of ETS oncogene family

PDB rendering based on 1dux.
Available structures
Symbols ELK1;
External IDs OMIM311040 MGI101833 HomoloGene3832 GeneCards: ELK1 Gene
RNA expression pattern
PBB GE ELK1 203617 x at tn.png
PBB GE ELK1 210376 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2002 13712
Ensembl ENSG00000126767 ENSMUSG00000009406
UniProt P19419 Q3V1M9
RefSeq (mRNA) NM_005229 NM_007922
RefSeq (protein) NP_005220 NP_031948
Location (UCSC) Chr X:
47.38 - 47.39 Mb
Chr X:
20.09 - 20.11 Mb
PubMed search [1] [2]

ELK1, member of ETS oncogene family, also known as ELK1, is a protein which humans is encoded by the ELK1 gene.[1] ELK1 stands for Ets LiKe gene1.



This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade.[2]


ELK1 has been shown to interact with EP300[3] and MAPK1.[4][5]


  1. ^ Rao VN, Huebner K, Isobe M, ar-Rushdi A, Croce CM, Reddy ES (April 1989). "elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints". Science 244 (4900): 66–70. PMID 2539641.  
  2. ^ "Entrez Gene: ELK1 ELK1, member of ETS oncogene family".  
  3. ^ Li, Qi-Jing; Yang Shen-Hsi, Maeda Yutaka, Sladek Frances M, Sharrocks Andrew D, Martins-Green Manuela (Jan. 2003). "MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300". EMBO J. (England) 22 (2): 281–91. doi:10.1093/emboj/cdg028. ISSN 0261-4189. PMID 12514134.  
  4. ^ Eblen, Scott T; Kumar N Vinay, Shah Kavita, Henderson Michelle J, Watts Colin K W, Shokat Kevan M, Weber Michael J (Apr. 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". J. Biol. Chem. (United States) 278 (17): 14926–35. doi:10.1074/jbc.M300485200. ISSN 0021-9258. PMID 12594221.  
  5. ^ Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell. Sci. (ENGLAND) 108 ( Pt 11): 3599–609. ISSN 0021-9533. PMID 8586671.  

Further reading

  • Rao VN, Huebner K, Isobe M, ar-Rushdi A, Croce CM, Reddy ES (April 1989). "elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints". Science (journal) 244 (4900): 66–70. doi:10.1126/science.2539641. PMID 2539641.  
  • Rao VN, Reddy ES (January 1993). "Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificity". Cancer Res. 53 (2): 215–20. PMID 8417810.  
  • Shao N, Chai Y, Cui JQ, Wang N, Aysola K, Reddy ES, Rao VN (July 1998). "Induction of apoptosis by Elk-1 and deltaElk-1 proteins". Oncogene 17 (4): 527–32. doi:10.1038/sj.onc.1201931. PMID 9696047.  
  • Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (March 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.  
  • Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family.". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.  
  • Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway.". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.  
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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