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ELK3, ETS-domain protein (SRF accessory protein 2)
Symbols ELK3; ERP; NET; SAP2
External IDs OMIM600247 MGI101762 HomoloGene3833 GeneCards: ELK3 Gene
RNA expression pattern
PBB GE ELK3 206127 at tn.png
PBB GE ELK3 221773 at tn.png
More reference expression data
Species Human Mouse
Entrez 2004 13713
Ensembl ENSG00000111145 ENSMUSG00000008398
UniProt P41970 Q3UZH4
RefSeq (mRNA) NM_005230 NM_013508
RefSeq (protein) NP_005221 NP_038536
Location (UCSC) Chr 12:
95.11 - 95.19 Mb
Chr 10:
92.68 - 92.74 Mb
PubMed search [1] [2]

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[1][2]

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[2]



ELK3 has been shown to interact with TCF3.[3]


  1. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.  
  2. ^ a b "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)".  
  3. ^ Maira, S M; Wurtz J M, Wasylyk B (Nov. 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. (ENGLAND) 15 (21): 5849–65. ISSN 0261-4189. PMID 8918463.  

Further reading

  • Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family.". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.  
  • Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway.". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.  
  • Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).". Embo J. 14 (11): 2589–601. PMID 7540136.  
  • Giovane A, Pintzas A, Maira SM, et al. (1994). "Net, a new ets transcription factor that is activated by Ras.". Genes Dev. 8 (13): 1502–13. doi:10.1101/gad.8.13.1502. PMID 7958835.  
  • Maira SM, Wurtz JM, Wasylyk B (1997). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.". Embo J. 15 (21): 5849–65. PMID 8918463.  
  • Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation.". Embo J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMID 10369679.  
  • Ducret C, Maira SM, Dierich A, Wasylyk B (2000). "The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock.". Mol. Cell. Biol. 19 (10): 7076–87. PMID 10490644.  
  • Ducret C, Maira SM, Lutz Y, Wasylyk B (2000). "The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades.". Oncogene 19 (44): 5063–72. doi:10.1038/sj.onc.1203892. PMID 11042694.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gupta M, Sueblinvong V, Raman J, et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wasylyk C, Criqui-Filipe P, Wasylyk B (2005). "Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net.". Oncogene 24 (5): 820–8. doi:10.1038/sj.onc.1208226. PMID 15580297.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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