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ELK4, ETS-domain protein (SRF accessory protein 1)

PDB rendering based on 1bc7.
Available structures
1bc7, 1bc8, 1hbx, 1k6o
Identifiers
Symbols ELK4; SAP1
External IDs OMIM600246 MGI102853 HomoloGene1492 GeneCards: ELK4 Gene
RNA expression pattern
PBB GE ELK4 206919 at tn.png
PBB GE ELK4 205994 at tn.png
PBB GE ELK4 214831 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2005 13714
Ensembl ENSG00000158711 ENSMUSG00000026436
UniProt P28324 Q8C6Q0
RefSeq (mRNA) NM_001973 NM_007923
RefSeq (protein) NP_001964 NP_031949
Location (UCSC) Chr 1:
203.83 - 203.87 Mb
Chr 1:
133.84 - 133.86 Mb
PubMed search [1] [2]

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[1][2][3]

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[3]

Contents

Interactions

ELK4 has been shown to interact with Serum response factor[4][5] and BRCA1.[6]

References

  1. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.  
  2. ^ Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773.  
  3. ^ a b "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2005.  
  4. ^ Hassler, M; Richmond T J (Jun. 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. (England) 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. ISSN 0261-4189. PMID 11406578.  
  5. ^ Zhu, C; Johansen F E, Prywes R (Sep. 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. (UNITED STATES) 17 (9): 4957–66. ISSN 0270-7306. PMID 9271374.  
  6. ^ Chai, Y; Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy E S, Rao V N (Mar. 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene (England) 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. ISSN 0950-9232. PMID 11313879.  

Further reading

  • Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family.". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.  
  • Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway.". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.  
  • Dalton S, Treisman R (1992). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.". Cell 68 (3): 597–612. doi:10.1016/0092-8674(92)90194-H. PMID 1339307.  
  • Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).". EMBO J. 14 (11): 2589–601. PMID 7540136.  
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.  
  • Dalton S, Treisman R (1994). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.". Cell 76 (2): 411. PMID 8293474.  
  • Janknecht R, Hunter T (1997). "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase.". J. Biol. Chem. 272 (7): 4219–24. doi:10.1074/jbc.272.7.4219. PMID 9020136.  
  • Janknecht R, Hunter T (1997). "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.". EMBO J. 16 (7): 1620–7. doi:10.1093/emboj/16.7.1620. PMID 9130707.  
  • Stein B, Yang MX, Young DB, et al. (1997). "p38-2, a novel mitogen-activated protein kinase with distinct properties.". J. Biol. Chem. 272 (31): 19509–17. doi:10.1074/jbc.272.31.19509. PMID 9235954.  
  • Mo Y, Vaessen B, Johnston K, Marmorstein R (1998). "Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.". Mol. Cell 2 (2): 201–12. doi:10.1016/S1097-2765(00)80130-6. PMID 9734357.  
  • Yates PR, Atherton GT, Deed RW, et al. (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors.". EMBO J. 18 (4): 968–76. doi:10.1093/emboj/18.4.968. PMID 10022839.  
  • Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus.". J. Biol. Chem. 274 (37): 26563–71. doi:10.1074/jbc.274.37.26563. PMID 10473620.  
  • Chai Y, Chipitsyna G, Cui J, et al. (2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells.". Oncogene 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.  
  • Hassler M, Richmond TJ (2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMID 11406578.  
  • Mo Y, Ho W, Johnston K, Marmorstein R (2002). "Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.". J. Mol. Biol. 314 (3): 495–506. doi:10.1006/jmbi.2001.5138. PMID 11846562.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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