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EMD-386,088: Wikis

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EMD-386,088
Systematic (IUPAC) name
5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
Identifiers
CAS number 54635-62-0
ATC code  ?
PubChem 10131112
Chemical data
Formula C 14H14ClN2  
Mol. mass 245.727 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

EMD-386,088 is an indole derivative which is used in scientific research. It acts as a potent and selective 5-HT6 receptor agonist, with a Ki of 1nM, a significantly higher affinity than older 5-HT6 agonists such as EMDT, although it does also have moderate affinity for the 5-HT3 receptor.[1]

References

  1. ^ Mattsson C, Sonesson C, Sandahl A, Greiner HE, Gassen M, Plaschke J, Leibrock J, Böttcher H. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorganic and Medicinal Chemistry Letters. 2005; 15(19):4230-4234. PMID 16055331
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