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EMDT
Systematic (IUPAC) name
2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
Identifiers
ATC code  ?
PubChem 6918513
Chemical data
Formula C15H22N2O 
Mol. mass 246.347 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor.[1] EMDT inhibits both long-term and short-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885.[2]

References

  1. ^ Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. Journal of Medicinal Chemistry. 2000 Mar 9;43(5):1011-8. PMID 10715164
  2. ^ Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E. The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behavioural Brain Research. 2008 Dec 16;195(1):112-9. PMID 18191236
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