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Egf-like module containing, mucin-like, hormone receptor-like 1
Symbols EMR1; TM7LN3
External IDs OMIM600493 MGI106912 HomoloGene1493 IUPHAR: EMR1 GeneCards: EMR1 Gene
RNA expression pattern
PBB GE EMR1 207111 at tn.png
More reference expression data
Species Human Mouse
Entrez 2015 13733
Ensembl ENSG00000174837 ENSMUSG00000004730
UniProt Q14246 Q3S4B0
RefSeq (mRNA) NM_001974 NM_010130
RefSeq (protein) NP_001965 NP_034260
Location (UCSC) Chr 19:
6.84 - 6.89 Mb
Chr 17:
57.04 - 57.17 Mb
PubMed search [1] [2]

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.[1][2][3]

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.[3]

See also


  1. ^ Baud V, Chissoe SL, Viegas-Pequignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (Aug 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334-44. PMID 7601460.  
  2. ^ McKnight AJ, Gordon S (Mar 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". J Leukoc Biol 63 (3): 271-80. PMID 9500513.  
  3. ^ a b "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".  

Further reading

  • McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene.". Mamm. Genome 8 (12): 946. doi:10.1007/s003359900633. PMID 9383301.  
  • Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication.". Mamm. Genome 10 (10): 1039–40. doi:10.1007/s003359901157. PMID 10501980.  
  • Lin HH, Stacey M, Hamann J, et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.". Genomics 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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