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Egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
Symbols EMR1; TM7LN3
External IDs OMIM600493 MGI106912 HomoloGene1493 IUPHAR: EMR1 GeneCards: EMR1 Gene
RNA expression pattern
PBB GE EMR1 207111 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2015 13733
Ensembl ENSG00000174837 ENSMUSG00000004730
UniProt Q14246 Q3S4B0
RefSeq (mRNA) NM_001974 NM_010130
RefSeq (protein) NP_001965 NP_034260
Location (UCSC) Chr 19:
6.84 - 6.89 Mb
Chr 17:
57.04 - 57.17 Mb
PubMed search [1] [2]

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.[1][2][3]

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.[3]

See also

References

  1. ^ Baud V, Chissoe SL, Viegas-Pequignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (Aug 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334-44. PMID 7601460.  
  2. ^ McKnight AJ, Gordon S (Mar 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". J Leukoc Biol 63 (3): 271-80. PMID 9500513.  
  3. ^ a b "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015.  

Further reading

  • McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene.". Mamm. Genome 8 (12): 946. doi:10.1007/s003359900633. PMID 9383301.  
  • Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication.". Mamm. Genome 10 (10): 1039–40. doi:10.1007/s003359901157. PMID 10501980.  
  • Lin HH, Stacey M, Hamann J, et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.". Genomics 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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