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Egf-like module containing, mucin-like, hormone receptor-like 2

PDB rendering based on 2bo2.
Available structures
2bo2, 2bou, 2box
Symbols EMR2; CD312; DKFZp781B135
External IDs OMIM606100 HomoloGene69138 IUPHAR: EMR2 GeneCards: EMR2 Gene
RNA expression pattern
PBB GE EMR2 207610 s at tn.png
More reference expression data
Species Human Mouse
Entrez 30817 n/a
Ensembl ENSG00000127507 n/a
UniProt Q9UHX3 n/a
RefSeq (mRNA) NM_013447 n/a
RefSeq (protein) NP_038475 n/a
Location (UCSC) Chr 19:
14.7 - 14.75 Mb
PubMed search [1] n/a

EGF-like module-containing mucin-like hormone receptor-like 2 is a protein that in humans is encoded by the EMR2 gene.[1] EMR2 has also been designated as CD312 (cluster of differentiation 312).

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms.[1]

See also


Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Lin HH, Stacey M, Hamann J, et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.". Genomics 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.  
  • Lin HH, Stacey M, Saxby C, et al. (2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.". J. Biol. Chem. 276 (26): 24160–9. doi:10.1074/jbc.M101770200. PMID 11297558.  
  • Kwakkenbos MJ, Chang GW, Lin HH, et al. (2002). "The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells.". J. Leukoc. Biol. 71 (5): 854–62. PMID 11994511.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Stacey M, Chang GW, Davies JQ, et al. (2003). "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.". Blood 102 (8): 2916–24. doi:10.1182/blood-2002-11-3540. PMID 12829604.  
  • Chang GW, Stacey M, Kwakkenbos MJ, et al. (2003). "Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.". FEBS Lett. 547 (1-3): 145–50. doi:10.1016/S0014-5793(03)00695-1. PMID 12860403.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Lin HH, Chang GW, Davies JQ, et al. (2004). "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.". J. Biol. Chem. 279 (30): 31823–32. doi:10.1074/jbc.M402974200. PMID 15150276.  
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.  
  • Chang GW, Davies JQ, Stacey M, et al. (2007). "CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells.". Biochem. Biophys. Res. Commun. 353 (1): 133–8. doi:10.1016/j.bbrc.2006.11.148. PMID 17174274.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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