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Egf-like module containing, mucin-like, hormone receptor-like 3
Symbols EMR3;
External IDs OMIM606101 HomoloGene50009 IUPHAR: EMR3 GeneCards: EMR3 Gene
RNA expression pattern
PBB GE EMR3 210724 at tn.png
More reference expression data
Species Human Mouse
Entrez 84658 n/a
Ensembl ENSG00000131355 n/a
UniProt Q9BY15 n/a
RefSeq (mRNA) NM_032571 n/a
RefSeq (protein) NP_115960 n/a
Location (UCSC) Chr 19:
14.57 - 14.65 Mb
PubMed search [1] n/a

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein that in humans is encoded by the EMR3 gene.[1][2][3]

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[3]

See also


  1. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (May 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J Biol Chem 276 (22): 18863-70. doi:10.1074/jbc.M101147200. PMID 11279179.  
  2. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.  
  3. ^ a b "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3".  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Matmati M, Pouwels W, van Bruggen R, et al. (2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.". J. Leukoc. Biol. 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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