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EN1 (gene): Wikis


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From Wikipedia, the free encyclopedia

Engrailed homeobox 1
Symbols EN1;
External IDs OMIM131290 MGI95389 HomoloGene50663 GeneCards: EN1 Gene
RNA expression pattern
PBB GE EN1 220559 at tn.png
More reference expression data
Species Human Mouse
Entrez 2019 13798
Ensembl ENSG00000163064 ENSMUSG00000058665
UniProt Q05925 Q3USA2
RefSeq (mRNA) NM_001426 XM_974086
RefSeq (protein) NP_001417 XP_979180
Location (UCSC) Chr 2:
119.32 - 119.32 Mb
Chr 1:
122.43 - 122.44 Mb
PubMed search [1] [2]

Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene.[1][2]

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.[2]


  1. ^ Kohler A, Logan C, Joyner AL, Muenke M (Mar 1993). "Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21". Genomics 15 (1): 233-5. doi:10.1006/geno.1993.1045. PMID 8094370.  
  2. ^ a b "Entrez Gene: EN1 engrailed homeobox 1".  

Further reading

  • Logan C, Hanks MC, Noble-Topham S, et al. (1993). "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.". Dev. Genet. 13 (5): 345–58. doi:10.1002/dvg.1020130505. PMID 1363401.  
  • Logan C, Willard HF, Rommens JM, Joyner AL (1989). "Chromosomal localization of the human homeo box-containing genes, EN1 and EN2.". Genomics 4 (2): 206–9. PMID 2567700.  
  • Kozmik Z, Sure U, Rüedi D, et al. (1995). "Deregulated expression of PAX5 in medulloblastoma.". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5709–13. PMID 7777574.  
  • Loomis CA, Harris E, Michaud J, et al. (1996). "The mouse Engrailed-1 gene and ventral limb patterning.". Nature 382 (6589): 360–3. doi:10.1038/382360a0. PMID 8684466.  
  • Joliot A, Trembleau A, Raposo G, et al. (1997). "Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties.". Development 124 (10): 1865–75. PMID 9169834.  
  • Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.". J. Biol. Chem. 276 (6): 4109–18. doi:10.1074/jbc.M008882200. PMID 11069920.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.  
  • Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins.". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells.". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMID 15839736.  
  • Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A (2006). "Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway.". Mol. Biol. Cell 17 (6): 2572–80. doi:10.1091/mbc.E06-01-0052. PMID 16571670.  
  • Atit R, Sgaier SK, Mohamed OA, et al. (2006). "Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse.". Dev. Biol. 296 (1): 164–76. doi:10.1016/j.ydbio.2006.04.449. PMID 16730693.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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