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Ectodermal-neural cortex (with BTB-like domain)
Symbols ENC1; CCL28; ENC-1; FLJ39259; KLHL35; NRPB; PIG10; TP53I10
External IDs OMIM605173 MGI109610 HomoloGene2694 GeneCards: ENC1 Gene
Species Human Mouse
Entrez 8507 13803
Ensembl n/a ENSMUSG00000041773
UniProt n/a Q8BRG4
RefSeq (mRNA) NM_003633 NM_007930
RefSeq (protein) NP_003624 NP_031956
Location (UCSC) n/a Chr 13:
98.34 - 98.35 Mb
PubMed search [1] [2]

Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.[1][2][3]

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM][3]


ENC1 has been shown to interact with Retinoblastoma protein.[2]


  1. ^ Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.  
  2. ^ a b Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S (Jun 1998). "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation". J Cell Biol 141 (3): 553–66. PMID 9566959.  
  3. ^ a b "Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)".  

Further reading

  • Hernandez MC, Andres-Barquin PJ, Holt I, Israel MA (1998). "Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors.". Exp. Cell Res. 242 (2): 470–7. doi:10.1006/excr.1998.4109. PMID 9683534.  
  • Hernandez MC, Andres-Barquin PJ, Kuo WL, Israel MA (2000). "Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization.". Cytogenet. Cell Genet. 87 (1-2): 89–90. doi:10.1159/000015398. PMID 10640818.  
  • Zhao L, Gregoire F, Sul HS (2000). "Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation.". J. Biol. Chem. 275 (22): 16845–50. doi:10.1074/jbc.275.22.16845. PMID 10828068.  
  • Kim TA, Ota S, Jiang S, et al. (2000). "Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors.". Gene 255 (1): 105–16. doi:10.1016/S0378-1119(00)00297-3. PMID 10974570.  
  • Fujita M, Furukawa Y, Tsunoda T, et al. (2001). "Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas.". Cancer Res. 61 (21): 7722–6. PMID 11691783.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Hammarsund M, Lerner M, Zhu C, et al. (2005). "Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia.". Hum. Mol. Genet. 13 (23): 2925–36. doi:10.1093/hmg/ddh315. PMID 15459180.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Seng S, Avraham HK, Jiang S, et al. (2007). "The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells.". Cancer Res. 67 (18): 8596–604. doi:10.1158/0008-5472.CAN-06-3785. PMID 17875699.  


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