The Full Wiki

More info on EP1 receptor

EP1 receptor: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Prostaglandin E receptor 1 (subtype EP1), 42kDa
Identifiers
Symbols PTGER1; EP1
External IDs OMIM176802 MGI97793 HomoloGene738 IUPHAR: EP1 GeneCards: PTGER1 Gene
RNA expression pattern
PBB GE PTGER1 214391 x at tn.png
PBB GE PTGER1 207650 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5731 19216
Ensembl ENSG00000160951 ENSMUSG00000019464
UniProt P34995 P35375
RefSeq (mRNA) NM_000955 NM_013641
RefSeq (protein) NP_000946 NP_038669
Location (UCSC) Chr 19:
14.44 - 14.45 Mb
Chr 8:
86.56 - 86.56 Mb
PubMed search [1] [2]

Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.[1]

Contents

See also

References

External links

Further reading

  • Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.  
  • Lee TY, Watanabe Y (1975). "A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems.". Japanese heart journal 16 (3): 243–56. PMID 1160156.  
  • Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.  
  • Funk CD, Furci L, FitzGerald GA, et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813.  
  • Kurihara Y, Endo H, Kondo H (2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.". Inflamm. Res. 50 (1): 1–5. doi:10.1007/s000110050716. PMID 11235015.  
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.". Mol. Vis. 8: 51–8. PMID 11951086.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsuoka Y, Furuyashiki T, Bito H, et al. (2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMID 12642666.  
  • Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. doi:10.1210/jc.2002-021475. PMID 12788892.  
  • Kitamura T, Itoh M, Noda T, et al. (2004). "Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.". Cancer Sci. 94 (7): 618–21. doi:10.1111/j.1349-7006.2003.tb01492.x. PMID 12841871.  
  • Moreland RB, Kim N, Nehra A, et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.". Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.  
  • Su JL, Shih JY, Yen ML, et al. (2004). "Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.". Cancer Res. 64 (2): 554–64. doi:10.1158/0008-5472.CAN-03-1301. PMID 14744769.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Han C, Wu T (2005). "Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.". J. Biol. Chem. 280 (25): 24053–63. doi:10.1074/jbc.M500562200. PMID 15855163.  
  • Nicola C, Timoshenko AV, Dixon SJ, et al. (2005). "EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.". J. Clin. Endocrinol. Metab. 90 (8): 4736–46. doi:10.1210/jc.2005-0413. PMID 15886234.  
  • Han C, Michalopoulos GK, Wu T (2006). "Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.". J. Cell. Physiol. 207 (1): 261–70. doi:10.1002/jcp.20560. PMID 16331686.  
  • Durrenberger PF, Facer P, Casula MA, et al. (2006). "Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.". BMC neurology 6: 1. doi:10.1186/1471-2377-6-1. PMID 16393343.  
  • McGraw DW, Mihlbachler KA, Schwarb MR, et al. (2006). "Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.". J. Clin. Invest. 116 (5): 1400–9. doi:10.1172/JCI25840. PMID 16670773.  
  • Horita H, Kuroda E, Hachisuga T, et al. (2007). "Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo.". Hum. Reprod. 22 (7): 1801–9. doi:10.1093/humrep/dem125. PMID 17525067.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message