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Prostaglandin E receptor 1 (subtype EP1), 42kDa
Symbols PTGER1; EP1
External IDs OMIM176802 MGI97793 HomoloGene738 IUPHAR: EP1 GeneCards: PTGER1 Gene
RNA expression pattern
PBB GE PTGER1 214391 x at tn.png
PBB GE PTGER1 207650 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5731 19216
Ensembl ENSG00000160951 ENSMUSG00000019464
UniProt P34995 P35375
RefSeq (mRNA) NM_000955 NM_013641
RefSeq (protein) NP_000946 NP_038669
Location (UCSC) Chr 19:
14.44 - 14.45 Mb
Chr 8:
86.56 - 86.56 Mb
PubMed search [1] [2]

Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.[1]


See also


External links

Further reading

  • Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.  
  • Lee TY, Watanabe Y (1975). "A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems.". Japanese heart journal 16 (3): 243–56. PMID 1160156.  
  • Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.  
  • Funk CD, Furci L, FitzGerald GA, et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813.  
  • Kurihara Y, Endo H, Kondo H (2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.". Inflamm. Res. 50 (1): 1–5. doi:10.1007/s000110050716. PMID 11235015.  
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.". Mol. Vis. 8: 51–8. PMID 11951086.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsuoka Y, Furuyashiki T, Bito H, et al. (2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMID 12642666.  
  • Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. doi:10.1210/jc.2002-021475. PMID 12788892.  
  • Kitamura T, Itoh M, Noda T, et al. (2004). "Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.". Cancer Sci. 94 (7): 618–21. doi:10.1111/j.1349-7006.2003.tb01492.x. PMID 12841871.  
  • Moreland RB, Kim N, Nehra A, et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.". Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.  
  • Su JL, Shih JY, Yen ML, et al. (2004). "Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.". Cancer Res. 64 (2): 554–64. doi:10.1158/0008-5472.CAN-03-1301. PMID 14744769.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Han C, Wu T (2005). "Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.". J. Biol. Chem. 280 (25): 24053–63. doi:10.1074/jbc.M500562200. PMID 15855163.  
  • Nicola C, Timoshenko AV, Dixon SJ, et al. (2005). "EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.". J. Clin. Endocrinol. Metab. 90 (8): 4736–46. doi:10.1210/jc.2005-0413. PMID 15886234.  
  • Han C, Michalopoulos GK, Wu T (2006). "Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.". J. Cell. Physiol. 207 (1): 261–70. doi:10.1002/jcp.20560. PMID 16331686.  
  • Durrenberger PF, Facer P, Casula MA, et al. (2006). "Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.". BMC neurology 6: 1. doi:10.1186/1471-2377-6-1. PMID 16393343.  
  • McGraw DW, Mihlbachler KA, Schwarb MR, et al. (2006). "Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.". J. Clin. Invest. 116 (5): 1400–9. doi:10.1172/JCI25840. PMID 16670773.  
  • Horita H, Kuroda E, Hachisuga T, et al. (2007). "Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo.". Hum. Reprod. 22 (7): 1801–9. doi:10.1093/humrep/dem125. PMID 17525067.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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