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ERF (gene): Wikis


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From Wikipedia, the free encyclopedia

Ets2 repressor factor
Symbols ERF; PE-2
External IDs MGI109637 HomoloGene68516 GeneCards: ERF Gene
RNA expression pattern
PBB GE ERF 203643 at tn.png
More reference expression data
Species Human Mouse
Entrez 2077 13875
Ensembl ENSG00000105722 ENSMUSG00000040857
UniProt P50548 Q3TXK4
RefSeq (mRNA) NM_006494 XM_990042
RefSeq (protein) NP_006485 XP_995136
Location (UCSC) Chr 19:
47.44 - 47.45 Mb
Chr 7:
24.95 - 24.96 Mb
PubMed search [1] [2]

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.[1][2][3]


  1. ^ Sgouras DN, Athanasiou MA, Beal GJ Jr, Fisher RJ, Blair DG, Mavrothalassitis GJ (Nov 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". EMBO J 14 (19): 4781-93. PMID 7588608.  
  2. ^ de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (Sep 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics 42 (2): 227-35. doi:10.1006/geno.1997.4730. PMID 9192842.  
  3. ^ "Entrez Gene: ERF Ets2 repressor factor".  

Further reading

  • Liu D, Pavlopoulos E, Modi W, et al. (1997). "ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes.". Oncogene 14 (12): 1445–51. doi:10.1038/sj.onc.1200965. PMID 9136988.  
  • Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G (1999). "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation.". Mol. Cell. Biol. 19 (6): 4121–33. PMID 10330152.  
  • Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.  
  • Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners.". FEBS Lett. 517 (1-3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bain M, Mendelson M, Sinclair J (2003). "Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells.". J. Gen. Virol. 84 (Pt 1): 41–9. doi:10.1099/vir.0.18633-0. PMID 12533699.  
  • Xiao X, Athanasiou M, Sidorov IA, et al. (2003). "Role of Ets/Id proteins for telomerase regulation in human cancer cells.". Exp. Mol. Pathol. 75 (3): 238–47. doi:10.1016/S0014-4800(03)00092-3. PMID 14611815.  
  • Wolvetang EJ, Bradfield OM, Hatzistavrou T, et al. (2004). "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis.". Neurobiol. Dis. 14 (3): 349–56. doi:10.1016/S0969-9961(03)00107-4. PMID 14678752.  
  • Le Gallic L, Virgilio L, Cohen P, et al. (2004). "ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression.". Mol. Cell. Biol. 24 (3): 1206–18. doi:10.1128/MCB.24.3.1206-1218.2004. PMID 14729966.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Hester KD, Verhelle D, Escoubet-Lozach L, et al. (2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.". Cell Cycle 6 (13): 1594–604. PMID 17525531.  
  • Verykokakis M, Papadaki C, Vorgia E, et al. (2007). "The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression.". J. Biol. Chem. 282 (41): 30285–94. doi:10.1074/jbc.M704428200. PMID 17699159.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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