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V-ets erythroblastosis virus E26 oncogene homolog (avian)

PDB rendering based on 1fli.
Available structures
1fli, 1sxe
Identifiers
Symbols ERG; erg-3; p55
External IDs OMIM165080 MGI95415 HomoloGene15848 GeneCards: ERG Gene
RNA expression pattern
PBB GE ERG 211626 x at tn.png
PBB GE ERG 213541 s at tn.png
PBB GE ERG 222079 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2078 13876
Ensembl ENSG00000157554 ENSMUSG00000040732
UniProt P11308 Q3UQJ4
RefSeq (mRNA) NM_004449 XM_001004957
RefSeq (protein) NP_004440 XP_001004957
Location (UCSC) Chr 21:
38.68 - 38.96 Mb
Chr 16:
95.47 - 95.52 Mb
PubMed search [1] [2]

V-ets erythroblastosis virus E26 oncogene homolog (avian), also known as ERG (Ets Related Gene), is a protein which in humans is encoded by the ERG gene.[1][2][3]

Contents

Interactions

ERG (gene) has been shown to interact with ETS2[4] and C-jun.[5]

References

  1. ^ "Entrez Gene: ERG v-ets erythroblastosis virus E26 oncogene homolog (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2078.  
  2. ^ Reddy ES, Rao VN, Papas TS (September 1987). "The erg gene: a human gene related to the ets oncogene". Proc. Natl. Acad. Sci. U.S.A. 84 (17): 6131–5. doi:10.1073/pnas.84.17.6131. PMID 3476934. PMC 299022. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=3476934.  
  3. ^ Rao VN, Modi WS, Drabkin HD, Patterson D, O'Brien SJ, Papas TS, Reddy ES (November 1988). "The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia". Oncogene 3 (5): 497–500. PMID 3274086.  
  4. ^ Basuyaux, J P; Ferreira E, Stéhelin D, Butticè G (Oct. 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". J. Biol. Chem. (UNITED STATES) 272 (42): 26188–95. ISSN 0021-9258. PMID 9334186.  
  5. ^ Verger, A; Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M (May. 2001). "Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation". J. Biol. Chem. (United States) 276 (20): 17181–9. doi:10.1074/jbc.M010208200. ISSN 0021-9258. PMID 11278640.  

Further reading

  • Reddy ES, Rao VN (December 1991). "erg, an ets-related gene, codes for sequence-specific transcriptional activators". Oncogene 6 (12): 2285–9. PMID 1766675.  
  • Siddique HR, Rao VN, Lee L, Reddy ES (July 1993). "Characterization of the DNA binding and transcriptional activation domains of the erg protein". Oncogene 8 (7): 1751–5. PMID 8510921.  
  • Yi H, Fujimura Y, Ouchida M, Prasad DD, Rao VN, Reddy ES (March 1997). "Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias". Oncogene 14 (11): 1259–68. doi:10.1038/sj.onc.1201099. PMID 9178886.  
  • Rao VN, Modi WS, Drabkin HD, et al. (1990). "The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia.". Oncogene 3 (5): 497–500. PMID 3274086.  
  • Rao VN, Papas TS, Reddy ES (1987). "erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.". Science 237 (4815): 635–9. doi:10.1126/science.3299708. PMID 3299708.  
  • Reddy ES, Rao VN, Papas TS (1987). "The erg gene: a human gene related to the ets oncogene.". Proc. Natl. Acad. Sci. U.S.A. 84 (17): 6131–5. doi:10.1073/pnas.84.17.6131. PMID 3476934.  
  • Giovannini M, Biegel JA, Serra M, et al. (1994). "EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.". J. Clin. Invest. 94 (2): 489–96. doi:10.1172/JCI117360. PMID 8040301.  
  • Dunn T, Praissman L, Hagag N, Viola MV (1994). "ERG gene is translocated in an Ewing's sarcoma cell line.". Cancer Genet. Cytogenet. 76 (1): 19–22. doi:10.1016/0165-4608(94)90063-9. PMID 8076344.  
  • Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994). "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.". Cancer Res. 54 (11): 2865–8. PMID 8187069.  
  • Prasad DD, Rao VN, Lee L, Reddy ES (1994). "Differentially spliced erg-3 product functions as a transcriptional activator.". Oncogene 9 (2): 669–73. PMID 8290279.  
  • Murakami K, Mavrothalassitis G, Bhat NK, et al. (1993). "Human ERG-2 protein is a phosphorylated DNA-binding protein--a distinct member of the ets family.". Oncogene 8 (6): 1559–66. PMID 8502479.  
  • Duterque-Coquillaud M, Niel C, Plaza S, Stehelin D (1993). "New human erg isoforms generated by alternative splicing are transcriptional activators.". Oncogene 8 (7): 1865–73. PMID 8510931.  
  • Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.". J. Biol. Chem. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.  
  • Carrère S, Verger A, Flourens A, et al. (1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.". Oncogene 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824.  
  • McLaughlin F, Ludbrook VJ, Kola I, et al. (2000). "Characterisation of the tumour necrosis factor (TNF)-(alpha) response elements in the human ICAM-2 promoter.". J. Cell. Sci. 112 ( Pt 24): 4695–703. PMID 10574717.  
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.  
  • Mastrangelo T, Modena P, Tornielli S, et al. (2000). "A novel zinc finger gene is fused to EWS in small round cell tumor.". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Verger A, Buisine E, Carrère S, et al. (2001). "Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation.". J. Biol. Chem. 276 (20): 17181–9. doi:10.1074/jbc.M010208200. PMID 11278640.  
  • Yang L, Xia L, Wu DY, et al. (2002). "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.". Oncogene 21 (1): 148–52. doi:10.1038/sj.onc.1204998. PMID 11791185.  
  • Mackereth CD, Schärpf M, Gentile LN, McIntosh LP (2003). "Chemical shift and secondary structure conservation of the PNT/SAM domains from the ets family of transcription factors.". J. Biomol. NMR 24 (1): 71–2. doi:10.1023/A:1020617426325. PMID 12449421.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsui Y, Chansky HA, Barahmand-Pour F, et al. (2003). "COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG.". J. Biol. Chem. 278 (13): 11369–75. doi:10.1074/jbc.M300164200. PMID 12554743.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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