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V-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

PDB rendering based on 1bqv.
Available structures
1bqv, 1gvj, 1k78, 1k79, 1k7a, 1md0, 1mdm, 1r36, 2stt, 2stw
Symbols ETS1; ETS-1; EWSR2; FLJ10768
External IDs OMIM164720 MGI95455 HomoloGene3837 GeneCards: ETS1 Gene
RNA expression pattern
PBB GE ETS1 214447 at tn.png
More reference expression data
Species Human Mouse
Entrez 2113 23871
Ensembl ENSG00000134954 ENSMUSG00000032035
UniProt P14921 Q540Q5
RefSeq (mRNA) NM_005238 NM_001038642
RefSeq (protein) NP_005229 NP_001033731
Location (UCSC) Chr 11:
127.83 - 127.9 Mb
Chr 9:
32.39 - 32.51 Mb
PubMed search [1] [2]

Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene.[1][1] The protein encoded by this gene belongs to the ETS family of transcription factors.[2]



ETS1 has been shown to interact with TTRAP,[3] UBE2I[4] and Death associated protein 6.[5]


  1. ^ a b Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G, et al. (Oct 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature 359 (6391): 162–5. doi:10.1038/359162a0. PMID 1522903.  
  2. ^ Dwyer J, Li H, Xu D, Liu JP (October 2007). "Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family". Ann. N. Y. Acad. Sci. 1114: 36–47. doi:10.1196/annals.1396.022. PMID 17986575.  
  3. ^ Pei, Huiping; Yordy John S, Leng Qixin, Zhao Qinghua, Watson Dennis K, Li Runzhao (May. 2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene (England) 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. ISSN 0950-9232. PMID 12743594.  
  4. ^ Hahn, S L; Wasylyk B, Criqui-Filipe P, Criqui P (Sep. 1997). "Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme". Oncogene (ENGLAND) 15 (12): 1489–95. doi:10.1038/sj.onc.1201301. ISSN 0950-9232. PMID 9333025.  
  5. ^ Li, R; Pei H, Watson D K, Papas T S (Feb. 2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes". Oncogene (ENGLAND) 19 (6): 745–53. doi:10.1038/sj.onc.1203385. ISSN 0950-9232. PMID 10698492.  

Further reading

  • Reddy ES, Rao VN (1988). "Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene". Oncogene Res. 3 (3): 239–46. PMID 3060801.  
  • Lincoln DW, Bove K (2006). "The transcription factor Ets-1 in breast cancer.". Front. Biosci. 10: 506–11. doi:10.2741/1546. PMID 15574387.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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