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Ets variant gene 4 (E1A enhancer binding protein, E1AF)
Identifiers
Symbols ETV4; E1A-F; E1AF; PEA3; PEAS3
External IDs OMIM600711 MGI99423 HomoloGene1504 GeneCards: ETV4 Gene
RNA expression pattern
PBB GE ETV4 211603 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2118 18612
Ensembl ENSG00000175832 ENSMUSG00000017724
UniProt P43268 Q3UMZ6
RefSeq (mRNA) NM_001079675 NM_008815
RefSeq (protein) NP_001073143 NP_032841
Location (UCSC) Chr 17:
38.96 - 38.98 Mb
Chr 11:
101.59 - 101.6 Mb
PubMed search [1] [2]

ETS translocation variant 4 is a protein that in humans is encoded by the ETV4 gene.[1][2]

References

  1. ^ Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Feb 1996). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics 28 (2): 357-9. doi:10.1006/geno.1995.1158. PMID 8530053.  
  2. ^ "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2118.  

Further reading

  • Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.". Genomics 25 (1): 256–63. doi:10.1016/0888-7543(95)80133-7. PMID 7774926.  
  • Liu SH, Peng BH, Ma JT, et al. (1995). "Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor.". Dev. Genet. 16 (3): 229–40. doi:10.1002/dvg.1020160303. PMID 7796532.  
  • Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "The search for BRCA1.". Cancer Res. 54 (24): 6374–82. PMID 7987831.  
  • Higashino F, Yoshida K, Fujinaga Y, et al. (1993). "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.". Nucleic Acids Res. 21 (3): 547–53. doi:10.1093/nar/21.3.547. PMID 8441666.  
  • Urano F, Umezawa A, Hong W, et al. (1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma.". Biochem. Biophys. Res. Commun. 219 (2): 608–12. doi:10.1006/bbrc.1996.0281. PMID 8605035.  
  • Coutte L, Monté D, Baert J, de Launoit Y (2000). "Genomic organization of the human e1af gene,a member of Ets transcription factors.". Gene 240 (1): 201–7. doi:10.1016/S0378-1119(99)00400-X. PMID 10564827.  
  • Mastrangelo T, Modena P, Tornielli S, et al. (2000). "A novel zinc finger gene is fused to EWS in small round cell tumor.". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Davidson B, Goldberg I, Gotlieb WH, et al. (2004). "PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma.". Clin. Cancer Res. 9 (4): 1412–9. PMID 12684413.  
  • Span PN, Manders P, Heuvel JJ, et al. (2004). "E1AF expression levels are not associated with prognosis in human breast cancer.". Breast Cancer Res. Treat. 79 (1): 129–31. doi:10.1023/A:1023338424677. PMID 12779089.  
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.  
  • Liu Y, Borchert GL, Phang JM (2004). "Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells.". J. Biol. Chem. 279 (18): 18694–700. doi:10.1074/jbc.M308136200. PMID 14976201.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Davidson B, Goldberg I, Tell L, et al. (2004). "The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions.". Clin. Exp. Metastasis 21 (3): 191–9. doi:10.1023/B:CLIN.0000037703.37275.35. PMID 15387369.  
  • Fauquette V, Perrais M, Cerulis S, et al. (2005). "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells.". Biochem. J. 386 (Pt 1): 35–45. doi:10.1042/BJ20040706. PMID 15461591.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zhu X, Jiang J, Shen H, et al. (2005). "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.". J. Biol. Chem. 280 (13): 12503–16. doi:10.1074/jbc.M413631200. PMID 15611127.  
  • Takahashi A, Higashino F, Aoyagi M, et al. (2005). "E1AF degradation by a ubiquitin-proteasome pathway.". Biochem. Biophys. Res. Commun. 327 (2): 575–80. doi:10.1016/j.bbrc.2004.12.045. PMID 15629152.  
  • Nosho K, Yoshida M, Yamamoto H, et al. (2005). "Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.". Carcinogenesis 26 (5): 892–9. doi:10.1093/carcin/bgi029. PMID 15695237.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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