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EXP-561: Wikis


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Systematic (IUPAC) name
CAS number 10206-89-0
16142-83-9 (hydrochloride monohydrate)
ATC code None
PubChem CID 27696
ChemSpider 25769
Chemical data
Formula C14H19N 
Mol. mass 201.31 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

EXP-561 is a drug which acts as a very potent inhibitor of the reuptake serotonin, dopamine, and norepinephrine.[1][2][3][4] It was developed in the 1960s and was suggested as a potential antidepressant but was never marketed.[4][5][6] EXP-561 is a rigid analogue of amphetamine,[1] but unlike amphetamine, does not act as a releaser of the monoamine neurotransmitters, and instead is a pure reuptake inhibitor more similarly to cocaine.[7]

See also


  1. ^ a b Fuller RW, Snoddy HD, Perry KW (November 1976). "Inhibition of amine uptake by 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561) in rats". Biochemical Pharmacology 25 (21): 2409–10. PMID 999731. 
  2. ^ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". The Journal of Pharmacology and Experimental Therapeutics 199 (3): 649–61. PMID 994022. 
  3. ^ Wong DT, Molloy BB, Bymaster FP (January 1977). [Expression error: Unexpected < operator "Blockade of monoamine uptake by 1-amino-4-phenylbicyclo(2,2,2)octane (EXP 561) in rat brain and heart"]. Neuropharmacology 16 (1): 11–5. PMID 834358. 
  4. ^ a b Maj J, Skuza G, Sowińska H, Nowak G (1987). [Expression error: Unexpected < operator "Pharmacological properties of EXP 561, a potential antidepressant drug"]. Journal of Neural Transmission 70 (1-2): 81–97. PMID 2822850. 
  5. ^ Lehmann HE, Ban TA, Debow SL (June 1967). [Expression error: Unexpected < operator "A clinical-pharmacological study with EXP 561"]. Current Therapeutic Research, Clinical and Experimental 9 (6): 306–8. PMID 4963065. 
  6. ^ Gershon S, Hekimian LJ, Floyd A (February 1968). [Expression error: Unexpected < operator "Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561)"]. Arzneimittel-Forschung 18 (2): 243–5. PMID 5695389. 
  7. ^ Ross SB, Kelder D (May 1979). [Expression error: Unexpected < operator "Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum"]. Acta Pharmacologica Et Toxicologica 44 (5): 329–35. PMID 474143. 

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