The Full Wiki

More info on EXP-561

EXP-561: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

EXP-561
Systematic (IUPAC) name
4-phenylbicyclo[2.2.2]octan-1-amine
Identifiers
CAS number 10206-89-0
16142-83-9 (hydrochloride monohydrate)
ATC code None
PubChem CID 27696
ChemSpider 25769
Chemical data
Formula C14H19N 
Mol. mass 201.31 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

EXP-561 is a drug which acts as a very potent inhibitor of the reuptake serotonin, dopamine, and norepinephrine.[1][2][3][4] It was developed in the 1960s and was suggested as a potential antidepressant but was never marketed.[4][5][6] EXP-561 is a rigid analogue of amphetamine,[1] but unlike amphetamine, does not act as a releaser of the monoamine neurotransmitters, and instead is a pure reuptake inhibitor more similarly to cocaine.[7]

See also

References

  1. ^ a b Fuller RW, Snoddy HD, Perry KW (November 1976). "Inhibition of amine uptake by 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561) in rats". Biochemical Pharmacology 25 (21): 2409–10. PMID 999731. http://linkinghub.elsevier.com/retrieve/pii/0006-2952(76)90039-3. 
  2. ^ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". The Journal of Pharmacology and Experimental Therapeutics 199 (3): 649–61. PMID 994022. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=994022. 
  3. ^ Wong DT, Molloy BB, Bymaster FP (January 1977). [Expression error: Unexpected < operator "Blockade of monoamine uptake by 1-amino-4-phenylbicyclo(2,2,2)octane (EXP 561) in rat brain and heart"]. Neuropharmacology 16 (1): 11–5. PMID 834358. 
  4. ^ a b Maj J, Skuza G, Sowińska H, Nowak G (1987). [Expression error: Unexpected < operator "Pharmacological properties of EXP 561, a potential antidepressant drug"]. Journal of Neural Transmission 70 (1-2): 81–97. PMID 2822850. 
  5. ^ Lehmann HE, Ban TA, Debow SL (June 1967). [Expression error: Unexpected < operator "A clinical-pharmacological study with EXP 561"]. Current Therapeutic Research, Clinical and Experimental 9 (6): 306–8. PMID 4963065. 
  6. ^ Gershon S, Hekimian LJ, Floyd A (February 1968). [Expression error: Unexpected < operator "Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561)"]. Arzneimittel-Forschung 18 (2): 243–5. PMID 5695389. 
  7. ^ Ross SB, Kelder D (May 1979). [Expression error: Unexpected < operator "Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum"]. Acta Pharmacologica Et Toxicologica 44 (5): 329–35. PMID 474143. 

Retrieved from "http://yak.rapint.com/wiki/EXP-561"
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message