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Systematic (IUPAC) name
CAS number 112108-01-7
ATC code none
PubChem 107930
Chemical data
Formula C 19H20ClNO 
Mol. mass 313.821 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ecopipam (SCH-39166) is a synthetic benzazepine derivative drug that acts as a selective dopamine D1/D5 receptor antagonist, with little affinity for either dopamine D2-like or 5-HT2 receptors.[1] It has sedative, antipsychotic and anorectic effects, and was researched for human use although never approved for medical prescription, mainly because of side effects such as depression and anxiety.[2][3]


  1. ^ Chipkin RE, Iorio LC, Coffin VL, McQuade RD, Berger JG, Barnett A (December 1988). "Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity". The Journal of Pharmacology and Experimental Therapeutics 247 (3): 1093–102. PMID 2905002.  
  2. ^ Hou D, Schumacher D (November 2001). "The selection of a commercial route for the D1 antagonist Sch-39166". Current Opinion in Drug Discovery & Development 4 (6): 792–9. PMID 11899619.  
  3. ^ Astrup A, Greenway FL, Ling W, Pedicone L, Lachowicz J, Strader CD, Kwan R (July 2007). "Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects". Obesity (Silver Spring, Md.) 15 (7): 1717–31. doi:10.1038/oby.2007.205. PMID 17636090.  


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