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Ecothiopate iodide: Wikis


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Systematic (IUPAC) name
2-diethoxyphosphorylsulfanylethyl-trimethyl-ammonium iodide
CAS number 6736-03-4
ATC code S01EB03
PubChem 10547
DrugBank APRD00942
Chemical data
Formula C9H23INO3PS 
Mol. mass 383.228 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Topical (eye drops)
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Echothiophate (Phospholine) is a parasympathomimetic and a phosphorothioate. It is an acetylcholinesterase inhibitor.[1]


It is used as an ocular antihypertensive in the treatment of chronic glaucoma and, in some cases, accommodative esotropia. It is available under several trade names such as Phospholine Iodide (Wyeth-Ayerst).

Ecothiopate binds irreversibly to cholinesterase. Because of the very slow rate at which echothiophate is hydrolyzed by cholinesterase, its effects can last a week or more. Adverse effects include muscle spasm and other systemic effects.


Wyeth Pharmaceuticals stopped manufacturing ecothiopate iodide in the US in 2003. After contacting the American Academy of Ophthalmology (AAO), Wyeth rescinded their decision and, according to AAO public relations representative Michelle Stephens, the AAO and Wyeth were in talks for about a year about manufacturing it. [2]

In the meantime, a worldwide shortage of the drug has occurred.




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