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Systematic (IUPAC) name
CAS number 119431-25-3
ATC code none
PubChem 60703
Chemical data
Formula C 20H23ClFNO 
Mol. mass 347.854 g/mol
SMILES eMolecules & PubChem
Synonyms Eliprodil
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Eliprodil (SL-82.0715) is a drug which acts as an NMDA antagonist, binding to the polyamine modulatory site.[1] It has neuroprotective and anticonvulsant effects in animal studies,[2] but does not support self administration or substitute for phencyclidine,[3] and does not produce sedation or amnesia.[4] It was researched for the treatment of stroke[5] and epilepsy[6] but human trials failed to show clear beneficial effects.[7]


  1. ^ Dereń-Wesołek A, Maj J. Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex. Polish Journal of Pharmacology. 1993 Sep-Dec;45(5-6):467-80. PMID 7912135
  2. ^ Toulmond S, Serrano A, Benavides J, Scatton B. Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window. Brain Research. 1993 Aug 20;620(1):32-41. PMID 8402196
  3. ^ Balster RL, Nicholson KL, Sanger DJ. Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats. Drug and Alcohol Dependence. 1994 Jun;35(3):211-6. PMID 7956750
  4. ^ Patat A, Molinier P, Hergueta T, Brohier S, Zieleniuk I, Danjou P, Warot D, Puech A. Lack of amnestic, psychotomimetic or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist. International Clinical Psychopharmacology. 1994 Sep;9(3):155-62. PMID 7814824
  5. ^ Reyes M, Reyes A, Opitz T, Kapin MA, Stanton PK. Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. Brain Research. 1998 Jan 26;782(1-2):212-8. PMID 9519265
  6. ^ Kohl BK, Dannhardt G. The NMDA receptor complex: a promising target for novel antiepileptic strategies. Current Medicinal Chemistry. 2001 Sep;8(11):1275-89. PMID 11562266
  7. ^ Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurology. 2002 Oct;1(6):383-6. PMID 12849400


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