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Elzasonan
Systematic (IUPAC) name
(E)-3-[3-[(4-ethylphenoxy)methyl]-4-methoxyphenyl]-1-(1-methyl-4-nitropyrazol-3-yl)prop-2-en-1-one
Identifiers
CAS number 220322-05-4
ATC code None
PubChem CID 19544192
Chemical data
Formula C22H21FN4O 
Mol. mass 421.44582 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Elzasonan (CP-448,187) is a selective 5-HT1B and 5-HT1D receptor antagonist that was under development by Pfizer for the treatment of depression but was discontinued, possibly due to poor efficacy.[1][2][3][4][5] By preferentially blocking 5-HT1B and 5-HT1D autoreceptors, elzasonan is thought to enhance serotonergic innervations originating from the raphe nucleus, thereby improving signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects.[3]

See also

References

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