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Enadoline
Systematic (IUPAC) name
2-(benzofuran-4-yl)-N-methyl-N-((5R,7S,8S)-7-

(pyrrolidin-1-yl)-1-oxaspiro[4.5] decan-8-yl)ethanamide

Identifiers
CAS number 124378-77-4
ATC code none
PubChem 60768
Chemical data
Formula C 24H32N2O3  
Mol. mass 396.52 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Enadoline is a drug which acts as a highly selective κ-opioid agonist.

In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of Salvinorin A.[1]

It was looked at as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.[2]

See also

References

  1. ^ Walsh SL, Strain EC, Abreu ME, Bigelow GE (2001). "Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans". Psychopharmacology (Berl.) 157 (2): 151–62. doi:10.1007/s002130100788. PMID 11594439.  
  2. ^ Barber A, Gottschlich R (1997). "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opin Investig Drugs 6 (10): 1351–68. doi:10.1517/13543784.6.10.1351. PMID 15989506.  
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