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Esmirtazapine
Systematic (IUPAC) name
(S)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine
Identifiers
CAS number 680993-85-5
ATC code none
PubChem 6451144
ChemSpider 4953625
Chemical data
Formula C21H23N3O4 
Mol. mass 381.43 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 114–116 °C (237–241 °F)
Solubility in water Soluble in methanol and chloroform mg/mL (20 °C)
Pharmacokinetic data
Metabolism Liver (CYP2D6)[1]
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Esmirtazapine (Org 50081) is a drug which is under development by Organon for the treatment of insomnia and vasomotor symptoms (e.g., hot flashes) associated with menopause.[2][3][4][5] As of 2009 it is in phase III clinical trials.[2] Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology, including inverse agonist actions at H1 and 5-HT2 receptors and antagonist actions at α2-adrenergic receptors.[2][6]

See also

References

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