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Estramustine: Wikis

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Estramustine
Systematic (IUPAC) name
(17β)-17-hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate
Identifiers
CAS number 2998-57-4
ATC code L01XX11
PubChem 18140
DrugBank APRD00625
Chemical data
Formula C 23H31Cl2NO3  
Mol. mass 440.403 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 20 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Estramustine (Emcyt, Estracit) is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen (specifically, estradiol) with an nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.

Estramustine is marketed in the United States by Pharmacia (now a subsidiary of Pfizer)

Clinical uses

Estramustine is indicated for the palliative treatment of metastatic and/or progressive carcinoma of the prostate.

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