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Estrogen related receptor: Wikis

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estrogen-related receptor alpha
Identifiers
Symbol ESRRA
Alt. symbols ESRL1
Entrez 2101
HUGO 3471
OMIM 601998
RefSeq NM_004451
UniProt P11474
Other data
Locus Chr. 11 q12
estrogen-related receptor beta
Identifiers
Symbol ESRRB
Alt. symbols ESRL2
Entrez 2103
HUGO 3473
OMIM 602167
RefSeq NM_004452
UniProt O95718
Other data
Locus Chr. 14 q24.3
estrogen-related receptor gamma
Identifiers
Symbol ESRRG
Entrez 2104
HUGO 3474
OMIM 602969
RefSeq NM_206595
UniProt P62508
Other data
Locus Chr. 1 q41

There are three known estrogen related receptors:

The ERRs are members of the orphan nuclear receptor family.

ERR's bind to estrogen response elements on DNA and modulate transcription but do not bind to endogenous estrogens.

In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer.[1]

References

  1. ^ Ariazi E, Jordan V (2006). "Estrogen-related receptors as emerging targets in cancer and metabolic disorders". Curr Top Med Chem 6 (3): 203–15. doi:10.2174/156802606776173483. PMID 16515477.  

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