The Full Wiki

More info on Etazolate

Etazolate: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Etazolate
Systematic (IUPAC) name
Ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate
Identifiers
CAS number 51022-77-6
ATC code none
PubChem 3277
Chemical data
Formula C 14H19N5O2  
Mol. mass 289.33 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Etazolate is a pyrazolopyridine derivative drug,[1] which acts as an anxiolytic.[2]

It has several mechanisms of action, acting as an adenosine antagonist,[3] a subtype-selective GABAA receptor partial agonist,[4] and a phosphodiesterase inhibitor selective for the PDE4 subtype.[5]

See also

References

  1. ^ Ticku MK, Davis WC (1982). "Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites". J. Neurochem. 38 (4): 1180–2. doi:10.1111/j.1471-4159.1982.tb05370.x. PMID 6278085.  
  2. ^ Williams M. Anxioselective anxiolytics. Journal of Medicinal Chemistry. 1983 May;26(5):619-28. PMID 6132997
  3. ^ Williams M, Jarvis MF. Adenosine antagonists as potential therapeutic agents. Pharmacology Biochemistry and Behaviour. 1988 Feb;29(2):433-41. PMID 3283781
  4. ^ Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 1996 Apr 22;301(1-3):207-14. PMID 8773466
  5. ^ Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and Biophysical Research Communications. 1997 May 19;234(2):320-4. PMID 9177268
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message