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Etazolate: Wikis


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Systematic (IUPAC) name
Ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate
CAS number 51022-77-6
ATC code none
PubChem 3277
Chemical data
Formula C 14H19N5O2  
Mol. mass 289.33 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Etazolate is a pyrazolopyridine derivative drug,[1] which acts as an anxiolytic.[2]

It has several mechanisms of action, acting as an adenosine antagonist,[3] a subtype-selective GABAA receptor partial agonist,[4] and a phosphodiesterase inhibitor selective for the PDE4 subtype.[5]

See also


  1. ^ Ticku MK, Davis WC (1982). "Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites". J. Neurochem. 38 (4): 1180–2. doi:10.1111/j.1471-4159.1982.tb05370.x. PMID 6278085.  
  2. ^ Williams M. Anxioselective anxiolytics. Journal of Medicinal Chemistry. 1983 May;26(5):619-28. PMID 6132997
  3. ^ Williams M, Jarvis MF. Adenosine antagonists as potential therapeutic agents. Pharmacology Biochemistry and Behaviour. 1988 Feb;29(2):433-41. PMID 3283781
  4. ^ Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 1996 Apr 22;301(1-3):207-14. PMID 8773466
  5. ^ Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and Biophysical Research Communications. 1997 May 19;234(2):320-4. PMID 9177268


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