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Ethcathinone: Wikis


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From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number 51553-17-4
ATC code none
PubChem  ?
Chemical data
Formula C 13H15NO 
Mol. mass 177.3 g/mol
Synonyms N-Ethylcathinone; 2-Ethylaminopropiophenone
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes oral, intranasal

Ethcathinone, also known as ethylpropion, is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is an active metabolite of diethylcathinone, of which acts as a prodrug to it, and is fully responsible for its effects. Ethcathinone has recently been reported as having been sold as "ecstasy" in the Australian city of Cairns, along with mephedrone.[1][2]



The pharmacology for ethylpropion appeared alongside other psychostimulants in a paper by Rothman and Baumann not long ago.[3] The predominant two modes of action for N-ethylpropion is as a moderately active releaser of noradrenaline (EC50 = 99.3 nM);[3] however it is only a relatively weak inhibitor of dopamine reuptake (Ki = 1014 nM).[3]

Since diethylpropion appears to be an inactive prodrug, and only becomes active after it has been further metabolized to ethylcathinone,[3] it thereby would appear rational to consider that the drug ethylpropion would also be expected to be N-dealkylated upon its consumption to the more active drug cathinone that is more able to reliably stimulate the release of dopamine. However, in contrast to diethylpropion, ethcathinone is not technically a prodrug since it is already active in its own right.

Legal Status

Denmark: Denmark's Minister for Health and Prevention Jakob Axel Nielsen banned ethylcathinone, mephedrone and flephedrone on Dec 18, 2008.

See also


  1. ^ Killer pills hit Cairns
  2. ^ Police warn of potentially fatal 'fake ecstasy'
  3. ^ a b c d Rothman RB, Baumann MH. Therapeutic potential of monoamine transporter substrates. Curr Top Med Chem. 2006;6(17):1845-59. PMID 17017961

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