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Ethoheptazine
Systematic (IUPAC) name
Ethyl 1-methyl-4-phenylazepane-4-carboxylate
Identifiers
CAS number 77-15-6
ATC code none
PubChem 6469
Chemical data
Formula C 16H23NO2  
Mol. mass 261.36 g/mol
Synonyms Zactane
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule V (US)
Routes Oral

Ethoheptazine (trade name Zactane) is an opioid analgesic from the phenazepine family. It was invented in the 1950s[1] and is related to other drugs such as proheptazine.[2]

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.[3] It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present.[4]

It is also contained in some formulations of Equagesic.[5]

References

  1. ^ Batterman RC, Golbey M, Grossman AJ, Leifer P. Analgesic effectiveness of orally administered ethoheptazine in man. American Journal of Medical Sciences. 1957 Oct;234(4):413-9.
  2. ^ Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.
  3. ^ Cinelli P, Zucchini M. Current pharmaco-therapeutic possibilities in the treatment of pain. Experiments with ethoeptazine. (Italian). Minerva Medica. 1962 Mar 3;53:637-42.
  4. ^ Scheiner JJ, Richards DJ. Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study. Current Therapeutic Research, Clinical and Experimental. 1974 Sep;16(9):928-36.
  5. ^ NetDoctor.co.uk
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