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Ethotoin: Wikis

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Systematic (IUPAC) name
CAS number 86-35-1
ATC code N03AB01
PubChem 3292
DrugBank APRD00962
Chemical data
Formula C 11H12N2O2  
Mol. mass 204.225 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3 to 9 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Oral

Ethotoin (marketed as Peganone by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Ethotoin lacks phenytoin's side effects of gingival hyperplasia and hirsutism, however it is less effective. This, combined with the need for frequent dosing has limited its usefulness. Ethotoin is no longer widely used.


Mechanism of action

Similar to phenytoin.

Approval history

  • 1957 Peganone was granted Food and Drug Administration (FDA) approval to Abbott Laboratories for treatment of grand mal (tonic clonic) and partial complex (psychomotor) seizures.
  • 2003 Peganone was acquired from Abbott Laboratories by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

Indications and usage

Ethotoin is indicated for tonic-clonic and partial complex seizures.


Ethotoin is available in 250mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.

Side effects

Ataxia, visual disturbances, rash and gastrointestinal problems.


Dis Nerv Syst. 1956 May;17(5):155-8.
Schwade ED, Richards RK, Everett GM. PMID 13317788

External links

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