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Ethoxzolamide: Wikis

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Ethoxzolamide
Systematic (IUPAC) name
6-ethoxy-1,3-benzothiazole-2-sulfonamide
Identifiers
CAS number 452-35-7
ATC code none
PubChem 3295
DrugBank APRD00732
Chemical data
Formula C9H10N2O3S2 
Mol. mass 258.319 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Protein binding ~89%
Half life 2.5-5.5 hours
Therapeutic considerations
Pregnancy cat.  ?
Legal status
 Yes check.svgY(what is this?)  (verify)

Ethoxzolamide (alternatively known as Ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. It is used in the treatment of glaucoma, duodenal ulcers, and as a diuretic. It may also be used in the treatment of some forms of epilepsy.

Pharmacology

Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Mechanism of action

Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems.

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