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House episode
"Euphoria, Part 2"
Episode no. HOU-221
Airdate May 3, 2006
Writer(s) Russel Friend & Garrett Lerner and David Shore
Director(s) Deran Sarafian
Guest star(s) Charles S. Dutton as Rodney Foreman
Scott Michael Campbell as Joe Luria
Final diagnosis Legionellosis (induced) and primary amoebic meningoencephalitis due to infection by Naegleria fowleri (Foreman)
Episode chronology
←  Previous Next  →
"Euphoria, Part 1" "Forever"
For the first part of this episode, see "Euphoria, Part 1"

"Euphoria, Part 2" is the twenty-first episode of the second season of House, which premiered on the FOX network on May 3, 2006. This is the conclusion to the House two-episode story arc, the first part being "Euphoria, Part 1".


The episode begins with House desperately trying to perform an autopsy on Joe, in order to find out which disease killed him. However, because the disease is contagious and has now killed one human, the situation has elevated to a Biohazard Level-3, which means no one other than CDC officials can perform an autopsy on Joe. As it will take at least 3 days for them to arrive, Foreman will be long dead before any such autopsy can be performed.

House then goads Foreman into performing the autopsy himself via a transorbital lobotomy, or "ice pick lobotomy," as Foreman will not be prosecuted if he's dead and is already infected. Cuddy arrives and tries to dissuade Foreman, but he attempts it anyway, only for his newest symptom to develop: Anton–Babinski syndrome, same as Joe, which prevents him from performing the operation correctly.

With the autopsy plan ruined, the team attempts another differential diagnosis. House, desperate, orders treatment for Foreman, treating everything: viruses, fungi, bacteria, parasites, etc. Foreman, also increasingly desperate, takes the drug cocktail. House then comes up with another plan: taking his pet rat, Steve McQueen, to Joe's apartment, House has Steve retrace all of Foreman's steps, in the hopes that it will catch the disease so House can perform a necropsy.

Foreman then calls his estranged father, telling him that he is sick and they should probably meet.

The drug cocktail successfully treats the disease that is killing Foreman, but the toxic combination also causes pancreatitis. Foreman wants to continue the treatment, preferring the pancreatitis over the blindness and hyperalgesia, but as he will die much sooner from the pancreatitis than from the unknown affliction, he finally agrees to stop treatment. Rodney Foreman, his father, then arrives, and House, realizing his opportunity, attempts to use him to guilt Cuddy into allowing the autopsy, but fails.

As Foreman makes up with his dad, the team discovers that Foreman is dying much quicker than Joe did. Trying to come up with reasons for why this is, House realizes it's because Foreman was completely healthy when he was infected. Cuddy then visits Foreman, offering her apologies, but though they are accepted, Foreman is furious, stating that even if she has to serve a prison sentence, her highest priority should be saving his life. ("What is the punishment for breaking those regulations? Is it death? Because I don't care if you get a fine, get suspended, hell, you can spend a few years in jail if it saves my life!")

As he is yelling at her, House arrives with a vial of Legionella, explaining that while Foreman was completely healthy when he was infected, Joe had Legionellosis. For some unknown reason, the Legionellosis slowed down the unknown disease. House then proceeds to purposely infect Foreman by shattering the vial of Legionella in the isolation chamber.

Back with the team, House then states that it's possible that an unknown infection is the culprit, which was not recognized by the body. However, the body was then infected with Legionella, which it recognized, causing an immune reaction. Putting together a disease that affects humans but not rats and a disease that the human body would not recognize, House postulates the unknown disease is Listeriosis.

However, Foreman initially refuses treatment, as it will definitely cure the Legionellosis but not necessarily the unknown disease, which means the pain will return. Treatment doesn't work, and Foreman, in increasing pain, asks Cameron to be his medical proxy. Because of the increasing pain, the team has no choice but to put Foreman into a coma, similar to Joe. Everyone knows there is a good chance Foreman will never wake up.

After Foreman has been put into a coma, Cameron, now his medical proxy, obliges his request and decides to perform a white-matter brain biopsy, a dangerous operation which could leave Foreman paralyzed, brain damaged, or killed. House, desperate to save Foreman without endangering his brain, decides to return to Joe's apartment, even without hazmat protection, to find another infected animal on which he can perform a necropsy.

As House is investigating Joe's apartment, the medical team is simultaneously preparing Foreman for the operation. House eventually discovers that Joe had an illegal well of rain water on his roof, which was contaminated by Naegleria fowleri. House calls and informs Cameron of this revelation, but Cameron has already performed the biopsy, and both teams have simultaneously discovered the true disease, primary amoebic meningoencephalitis.

As Foreman wakes up from his coma, House performs a checkup of his brain function. House and Cameron then realize Foreman's lobes are crossed when he attempts to lift his right arm, but his left arm moves instead.

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