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Technetium (99mTc) exametazime
Systematic (IUPAC) name
[[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium (99mTc)
Identifiers
CAS number  ?
100551-63-1 (exametazime)
ATC code V09AA01
V09HA02 (labelled leucocytes)
PubChem 9552069
Chemical data
Formula C 13H25N4O3Tc 
Mol. mass 384.3655 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat.  ?
Legal status -only (US)
Routes Intravenous

Technetium (99mTc) exametazime (trade name Ceretec) is a drug used for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases, and for the labelling of leucocytes to localise intra-abdominal infections[2] and inflammatory bowel disease[3].

Chemistry

Exametazime (hexamethylpropyleneamine oxime, HMPAO)

The drug consists of two of the three stereoisomers of exametazime (hexamethylpropyleneamine oxime, HMPAO), the one shown and its enantiomer.[4] (The third is the meso form.) Exametazime acts as a chelating agent for the radioisotope technetium-99m.

References

  1. ^ Moretti, JL; Defer, G; Cinotti, L; Cesaro, P; Degos, JD; Vigneron, N; Ducassou, D; Holman, BL (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.   edit
  2. ^ Weldon, MJ; Joseph, AE; French, A; Saverymuttu, SH; Maxwell, JD (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–64. doi:10.1136/gut.37.4.557. PMID 7489945.   edit
  3. ^ Ui, K; Yamaguchi, T (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–6. PMID 1804909.   edit
  4. ^ Monography in the European Pharmacopoeia

External links

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Exametazime
Systematic (IUPAC) name
N-[(3R)-3-[[3-[[(2R,3E)-3-Hydroxyiminobutan-2-yl]amino]-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
Identifiers
CAS number 105613-48-7
ATC code V09AA01 (99mTc labelled),
V09HA02 (labelled leucocytes)
PubChem 9552071
Chemical data
Formula C13H28N4O2 
Mol. mass 272.387 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat.

?

Legal status

-only(US)

Routes Intravenous

Exametazime, labelled with the radioisotope technetium-99m, is a drug used for the detection of altered regional cerebral perfusion in stroke, and for the labelling of leucocytes to localise intra-abdominal infections and inflammatory bowel disease.

Technetium (99mTc) exametazime has the brand name Ceretec.

External links


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