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Coagulation factor II (thrombin) receptor-like 2
Symbols F2RL2; PAR3
External IDs OMIM601919 MGI1298208 HomoloGene36151 IUPHAR: PAR3 GeneCards: F2RL2 Gene
RNA expression pattern
PBB GE F2RL2 206795 at tn.png
More reference expression data
Species Human Mouse
Entrez 2151 14064
Ensembl ENSG00000164220 ENSMUSG00000021675
UniProt O00254 Q3UXV3
RefSeq (mRNA) NM_004101 NM_010170
RefSeq (protein) NP_004092 NP_034300
Location (UCSC) Chr 5:
75.95 - 75.95 Mb
Chr 13:
96.8 - 96.8 Mb
PubMed search [1] [2]

Protease activated receptor 3 (PAR3), previously known as Coagulation factor II (thrombin) receptor-like 2, is aprotein encoded by the F2RL2 gene in humans .

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[1]


See also


External links

Further reading

  • Hollenberg MD, Compton SJ (2002). "International Union of Pharmacology. XXVIII. Proteinase-activated receptors.". Pharmacol. Rev. 54 (2): 203–17. doi:10.1124/pr.54.2.203. PMID 12037136.  
  • Ishihara H, Connolly AJ, Zeng D, et al. (1997). "Protease-activated receptor 3 is a second thrombin receptor in humans.". Nature 386 (6624): 502–6. doi:10.1038/386502a0. PMID 9087410.  
  • Schmidt VA, Nierman WC, Maglott DR, et al. (1998). "The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.". J. Biol. Chem. 273 (24): 15061–8. doi:10.1074/jbc.273.24.15061. PMID 9614115.  
  • Xu WF, Andersen H, Whitmore TE, et al. (1998). "Cloning and characterization of human protease-activated receptor 4.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. doi:10.1073/pnas.95.12.6642. PMID 9618465.  
  • Guyonnet Dupérat V, Jacquelin B, Boisseau P, et al. (1998). "Protease-activated receptor genes are clustered on 5q13.". Blood 92 (1): 25–31. PMID 9639495.  
  • Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation.". Nature 394 (6694): 690–4. doi:10.1038/29325. PMID 9716134.  
  • Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.". J. Biol. Chem. 273 (36): 23290–6. doi:10.1074/jbc.273.36.23290. PMID 9722561.  
  • Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.". J. Clin. Invest. 103 (6): 879–87. doi:10.1172/JCI6042. PMID 10079109.  
  • Hauck RW, Schulz C, Schömig A, et al. (1999). "alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors.". Am. J. Physiol. 277 (1 Pt 1): L22–9. PMID 10409227.  
  • Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin.". Nature 404 (6778): 609–13. doi:10.1038/35007085. PMID 10766244.  
  • O'Brien PJ, Prevost N, Molino M, et al. (2000). "Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.". J. Biol. Chem. 275 (18): 13502–9. doi:10.1074/jbc.275.18.13502. PMID 10788464.  
  • Cumashi A, Ansuini H, Celli N, et al. (2001). "Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets.". Thromb. Haemost. 85 (3): 533–8. PMID 11307827.  
  • Sambrano GR, Weiss EJ, Zheng YW, et al. (2001). "Role of thrombin signalling in platelets in haemostasis and thrombosis.". Nature 413 (6851): 74–8. doi:10.1038/35092573. PMID 11544528.  
  • Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.". J. Immunol. 167 (11): 6615–22. PMID 11714832.  
  • Uehara A, Sugawara S, Muramoto K, Takada H (2002). "Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2.". J. Immunol. 169 (8): 4594–603. PMID 12370398.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Even-Ram SC, Grisaru-Granovsky S, Pruss D, et al. (2003). "The pattern of expression of protease-activated receptors (PARs) during early trophoblast development.". J. Pathol. 200 (1): 47–52. doi:10.1002/path.1338. PMID 12692840.  
  • Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin.". Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.  
  • Tanaka N, Morita T, Nezu A, et al. (2003). "Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1).". Life Sci. 73 (3): 301–10. doi:10.1016/S0024-3205(03)00269-8. PMID 12757837.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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