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Fc fragment of IgA, receptor for

PDB rendering based on 1ovz.
Available structures
1ovz, 1ow0, 1uct
Symbols FCAR; CD89
External IDs OMIM147045 HomoloGene48064 GeneCards: FCAR Gene
RNA expression pattern
PBB GE FCAR 211307 s at tn.png
PBB GE FCAR 211816 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2204 n/a
Ensembl ENSG00000186431 n/a
UniProt P24071 n/a
RefSeq (mRNA) NM_002000 n/a
RefSeq (protein) NP_001991 n/a
Location (UCSC) Chr 19:
60.08 - 60.1 Mb
PubMed search [1] n/a

Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human gene.[1]

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.[1]



FCAR has been shown to interact with FCGR1A.[2]

See also


  1. ^ a b "Entrez Gene: FCAR Fc fragment of IgA, receptor for".  
  2. ^ Morton, H C; van den Herik-Oudijk I E, Vossebeld P, Snijders A, Verhoeven A J, Capel P J, van de Winkel J G (Dec. 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". J. Biol. Chem. (UNITED STATES) 270 (50): 29781–7. ISSN 0021-9258. PMID 8530370.  

Further reading

  • Morton HC, van Egmond M, van de Winkel JG (1997). "Structure and function of human IgA Fc receptors (Fc alpha R).". Crit. Rev. Immunol. 16 (4): 423–40. PMID 8954257.  
  • Morton HC, Brandtzaeg P (2001). "CD89: the human myeloid IgA Fc receptor.". Arch. Immunol. Ther. Exp. (Warsz.) 49 (3): 217–29. PMID 11478396.  
  • Martin AM, Kulski JK, Witt C, et al. (2002). "Leukocyte Ig-like receptor complex (LRC) in mice and men.". Trends Immunol. 23 (2): 81–8. doi:10.1016/S1471-4906(01)02155-X. PMID 11929131.  
  • Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors.". Annu. Rev. Immunol. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.  
  • Kremer EJ, Kalatzis V, Baker E, et al. (1992). "The gene for the human IgA Fc receptor maps to 19q13.4.". Hum. Genet. 89 (1): 107–8. doi:10.1007/BF00207054. PMID 1577457.  
  • Maliszewski CR, March CJ, Schoenborn MA, et al. (1991). "Expression cloning of a human Fc receptor for IgA.". J. Exp. Med. 172 (6): 1665–72. doi:10.1084/jem.172.6.1665. PMID 2258698.  
  • Pfefferkorn LC, Yeaman GR (1994). "Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2.". J. Immunol. 153 (7): 3228–36. PMID 7522255.  
  • de Wit TP, Morton HC, Capel PJ, van de Winkel JG (1995). "Structure of the gene for the human myeloid IgA Fc receptor (CD89).". J. Immunol. 155 (3): 1203–9. PMID 7636188.  
  • Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M (1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro.". J. Leukoc. Biol. 55 (4): 545–51. PMID 8145026.  
  • Monteiro RC, Hostoffer RW, Cooper MD, et al. (1993). "Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals.". J. Clin. Invest. 92 (4): 1681–5. doi:10.1172/JCI116754. PMID 8408621.  
  • Morton HC, van den Herik-Oudijk IE, Vossebeld P, et al. (1996). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association.". J. Biol. Chem. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.  
  • Morton HC, Schiel AE, Janssen SW, van de Winkel JG (1996). "Alternatively spliced forms of the human myeloid Fc alpha receptor (CD89) in neutrophils.". Immunogenetics 43 (4): 246–7. doi:10.1007/s002510050057. PMID 8575829.  
  • Patry C, Sibille Y, Lehuen A, Monteiro RC (1996). "Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages.". J. Immunol. 156 (11): 4442–8. PMID 8666819.  
  • Carayannopoulos L, Hexham JM, Capra JD (1996). "Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1.". J. Exp. Med. 183 (4): 1579–86. doi:10.1084/jem.183.4.1579. PMID 8666916.  
  • Pleass RJ, Andrews PD, Kerr MA, Woof JM (1996). "Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils.". Biochem. J. 318 ( Pt 3): 771–7. PMID 8836118.  
  • Reterink TJ, Verweij CL, van Es LA, Daha MR (1996). "Alternative splicing of IgA Fc receptor (CD89) transcripts.". Gene 175 (1-2): 279–80. doi:10.1016/0378-1119(96)00152-7. PMID 8917112.  
  • van Dijk TB, Bracke M, Caldenhoven E, et al. (1996). "Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils.". Blood 88 (11): 4229–38. PMID 8943858.  
  • Toyabe S, Kuwano Y, Takeda K, et al. (1997). "IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells.". Clin. Exp. Immunol. 110 (2): 226–32. PMID 9367406.  
  • Gulle H, Samstag A, Eibl MM, Wolf HM (1998). "Physical and functional association of Fc alpha R with protein tyrosine kinase Lyn.". Blood 91 (2): 383–91. PMID 9427690.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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