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FCGR1A: Wikis


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Fc fragment of IgG, high affinity Ia, receptor (CD64)
Symbols FCGR1A; CD64; CD64A; FCRI; IGFR1
External IDs OMIM146760 MGI95498 HomoloGene475 GeneCards: FCGR1A Gene
RNA expression pattern
PBB GE FCGR1A 216950 s at tn.png
PBB GE FCGR1A 214511 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2209 14129
Ensembl ENSG00000150337 ENSMUSG00000015947
UniProt P12314 P26151
RefSeq (mRNA) NM_000566 NM_010186
RefSeq (protein) NP_000557 NP_034316
Location (UCSC) Chr 1:
148.02 - 148.03 Mb
Chr 3:
96.37 - 96.38 Mb
PubMed search [1] [2]

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[1][2][3]


FCGR1A has been shown to interact with FCAR.[4]


  1. ^ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (Sep 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenet Cell Genet 73 (3): 157–63. PMID 8697799.  
  2. ^ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (Nov 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenet Cell Genet 82 (1-2): 71–4. PMID 9763663.  
  3. ^ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".  
  4. ^ Morton, H C; van den Herik-Oudijk I E, Vossebeld P, Snijders A, Verhoeven A J, Capel P J, van de Winkel J G (Dec. 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". J. Biol. Chem. (UNITED STATES) 270 (50): 29781–7. ISSN 0021-9258. PMID 8530370.  

Further reading

  • Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors.". Annu. Rev. Immunol. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.  
  • Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.". J. Biol. Chem. 267 (22): 15692–700. PMID 1379234.  
  • Benech PD, Sastry K, Iyer RR, et al. (1992). "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.". J. Exp. Med. 176 (4): 1115–23. doi:10.1084/jem.176.4.1115. PMID 1402657.  
  • Porges AJ, Redecha PB, Doebele R, et al. (1992). "Novel Fc gamma receptor I family gene products in human mononuclear cells.". J. Clin. Invest. 90 (5): 2102–9. doi:10.1172/JCI116094. PMID 1430234.  
  • van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (1991). "Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene.". J. Biol. Chem. 266 (20): 13449–55. PMID 1830050.  
  • Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts.". Intervirology 29 (6): 339–45. PMID 2852656.  
  • Allen JM, Seed B (1989). "Isolation and expression of functional high-affinity Fc receptor complementary DNAs.". Science 243 (4889): 378–81. doi:10.1126/science.2911749. PMID 2911749.  
  • Allen JM, Seed B (1989). "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).". Nucleic Acids Res. 16 (24): 11824. doi:10.1093/nar/16.24.11824. PMID 2974947.  
  • Indik ZK, Hunter S, Huang MM, et al. (1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.". Exp. Hematol. 22 (7): 599–606. PMID 7516890.  
  • Valerius T, Repp R, de Wit TP, et al. (1993). "Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy.". Blood 82 (3): 931–9. PMID 7687898.  
  • Wang AV, Scholl PR, Geha RS (1994). "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.". J. Exp. Med. 180 (3): 1165–70. doi:10.1084/jem.180.3.1165. PMID 8064233.  
  • Takai S, Kasama M, Yamada K, et al. (1994). "Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization.". Hum. Genet. 93 (1): 13–5. doi:10.1007/BF00218905. PMID 8270248.  
  • Morton HC, van den Herik-Oudijk IE, Vossebeld P, et al. (1996). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association.". J. Biol. Chem. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.  
  • De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.". Blood 91 (6): 2108–17. PMID 9490697.  
  • Kyono WT, de Jong R, Park RK, et al. (1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).". J. Immunol. 161 (10): 5555–63. PMID 9820532.  
  • Fanger NA, Cosman D, Peterson L, et al. (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.". Eur. J. Immunol. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.  
  • Gorgani NN, Altin JG, Parish CR (1999). "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes.". Int. Immunol. 11 (8): 1275–82. doi:10.1093/intimm/11.8.1275. PMID 10421785.  
  • Tridandapani S, Lyden TW, Smith JL, et al. (2000). "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.". J. Biol. Chem. 275 (27): 20480–7. doi:10.1074/jbc.M909462199. PMID 10781611.  


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