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FCGR2B: Wikis


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Fc fragment of IgG, low affinity IIb, receptor (CD32)

PDB rendering based on 1fcg.
Available structures
1fcg, 1h9v, 2fcb
Symbols FCGR2B; CD32; FCG2; FCGR2; IGFR2; CD32B
External IDs OMIM604590 MGI95499 HomoloGene2974 GeneCards: FCGR2B Gene
Species Human Mouse
Entrez 2213 14130
Ensembl n/a ENSMUSG00000026656
UniProt n/a P97918
RefSeq (mRNA) XM_001129592 NM_001077189
RefSeq (protein) XP_001129592 NP_001070657
Location (UCSC) n/a Chr 1:
172.8 - 172.81 Mb
PubMed search [1] [2]

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that in humans is encoded by the FCGR2B gene.[1][2] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif.


See also


  1. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732-5. PMID 2139735.  
  2. ^ "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)".  

Further reading

  • Tsuchiya N, Kyogoku C (2005). "Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia.". Autoimmunity 38 (5): 347–52. doi:10.1080/08916930500123926. PMID 16227149.  
  • Engelhardt W, Geerds C, Frey J (1990). "Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.". Eur. J. Immunol. 20 (6): 1367–77. doi:10.1002/eji.1830200624. PMID 2142460.  
  • Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor.". Immunogenetics 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077.  
  • Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMID 2529342.  
  • Stuart SG, Simister NE, Clarkson SB, et al. (1990). "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.". Embo J. 8 (12): 3657–66. PMID 2531080.  
  • Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.". Embo J. 7 (4): 1053–9. PMID 3402431.  
  • Engelhardt W, Matzke J, Schmidt RE (1995). "Activation-dependent expression of low affinity IgG receptors Fc gamma RII(CD32) and Fc gamma RIII(CD16) in subpopulations of human T lymphocytes.". Immunobiology 192 (5): 297–320. PMID 7649565.  
  • D'Ambrosio D, Hippen KL, Minskoff SA, et al. (1995). "Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.". Science 268 (5208): 293–7. doi:10.1126/science.7716523. PMID 7716523.  
  • Warmerdam PA, van den Herik-Oudijk IE, Parren PW, et al. (1993). "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses.". Int. Immunol. 5 (3): 239–47. doi:10.1093/intimm/5.3.239. PMID 8466861.  
  • Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. PMID 8756631.  
  • Sandilands GP, MacPherson SA, Burnett ER, et al. (1997). "Differential expression of CD32 isoforms following alloactivation of human T cells.". Immunology 91 (2): 204–11. doi:10.1046/j.1365-2567.1997.00241.x. PMID 9227318.  
  • De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.". Blood 91 (6): 2108–17. PMID 9490697.  
  • Metes D, Ernst LK, Chambers WH, et al. (1998). "Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.". Blood 91 (7): 2369–80. PMID 9516136.  
  • Sondermann P, Huber R, Jacob U (1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". Embo J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMID 10064577.  
  • Muraille E, Bruhns P, Pesesse X, et al. (2000). "The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling.". Immunol. Lett. 72 (1): 7–15. doi:10.1016/S0165-2478(00)00162-0. PMID 10789675.  
  • Pricop L, Redecha P, Teillaud JL, et al. (2001). "Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines.". J. Immunol. 166 (1): 531–7. PMID 11123333.  
  • Lyden TW, Robinson JM, Tridandapani S, et al. (2001). "The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2.". J. Immunol. 166 (6): 3882–9. PMID 11238632.  
  • Bharadwaj D, Mold C, Markham E, Du Clos TW (2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.". J. Immunol. 166 (11): 6735–41. PMID 11359830.  
  • Jessup CF, Ridings J, Ho A, et al. (2001). "The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes.". Hum. Immunol. 62 (7): 679–85. doi:10.1016/S0198-8859(01)00257-9. PMID 11423173.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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