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FCGR3B: Wikis


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From Wikipedia, the free encyclopedia

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

PDB rendering based on 1e4j.
Available structures
1e4j, 1e4k, 1fnl, 1iis, 1iix, 1t83, 1t89
Symbols FCGR3B; CD16; FCG3; FCGR3; CD16b
External IDs OMIM610665 HomoloGene88333 GeneCards: FCGR3B Gene
RNA expression pattern
PBB GE FCGR3B 204007 at tn.png
PBB GE FCGR3B 204006 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2215 n/a
Ensembl ENSG00000162747 n/a
UniProt O75015 n/a
RefSeq (mRNA) NM_000570 n/a
RefSeq (protein) NP_000561 n/a
Location (UCSC) Chr 1:
159.86 - 159.87 Mb
PubMed search [1] n/a

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.[1]

See also


Further reading

  • Qiu WQ, de Bruin D, Brownstein BH, et al. (1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.  
  • Peltz GA, Grundy HO, Lebo RV, et al. (1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMID 2521732.  
  • Scallon BJ, Scigliano E, Freedman VH, et al. (1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMID 2525780.  
  • Ravetch JV, Perussia B (1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.". J. Exp. Med. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMID 2526846.  
  • Simmons D, Seed B (1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.". Nature 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.  
  • Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.". J. Biol. Chem. 270 (3): 1350–61. PMID 7836402.  
  • Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (1997). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene.". J. Biol. Chem. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.  
  • Bux J, Stein EL, Bierling P, et al. (1997). "Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb.". Blood 89 (3): 1027–34. PMID 9028335.  
  • Zocchi MR, Rubartelli A, Morgavi P, Poggi A (1998). "HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels.". J. Immunol. 161 (6): 2938–43. PMID 9743356.  
  • Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.". Nature 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521.  
  • Zhang Y, Boesen CC, Radaev S, et al. (2000). "Crystal structure of the extracellular domain of a human Fc gamma RIII.". Immunity 13 (3): 387–95. doi:10.1016/S1074-7613(00)00038-8. PMID 11021536.  
  • Watanabe Y, Shimada E, Fujiwara K, et al. (2001). "Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.". Tissue Antigens 56 (3): 272–5. doi:10.1034/j.1399-0039.2000.560310.x. PMID 11034564.  
  • Bharadwaj D, Mold C, Markham E, Du Clos TW (2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.". J. Immunol. 166 (11): 6735–41. PMID 11359830.  
  • Davoine F, Lavigne S, Chakir J, et al. (2002). "Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions.". J. Allergy Clin. Immunol. 109 (3): 463–9. doi:10.1067/mai.2002.121952. PMID 11897993.  
  • Fossati G, Moots RJ, Bucknall RC, Edwards SW (2002). "Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes.". Arthritis Rheum. 46 (5): 1351–61. doi:10.1002/art.10230. PMID 12115243.  
  • Cauza K, Grassauer A, Hinterhuber G, et al. (2003). "FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma.". J. Invest. Dermatol. 119 (5): 1074–9. doi:10.1046/j.1523-1747.2002.19527.x. PMID 12445195.  
  • Siriboonrit U, Tsuchiya N, Sirikong M, et al. (2004). "Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais.". Tissue Antigens 61 (5): 374–83. doi:10.1034/j.1399-0039.2003.00047.x. PMID 12753656.  
  • Breij EC, van der Pol WL, van Winsen L, et al. (2003). "No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS.". J. Neuroimmunol. 140 (1-2): 210–5. PMID 12864991.  
  • Tong Y, Jin J, Yan L, et al. (2003). "FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province.". Ann. Hematol. 82 (9): 574–8. doi:10.1007/s00277-003-0725-y. PMID 12898191.  
  • Tanaka S, Edberg JC, Chatham W, et al. (2004). "Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins.". J. Immunol. 171 (11): 6090–6. PMID 14634123.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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