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Fibroblast growth factor 10

PDB rendering based on 1nun.
Available structures
Symbols FGF10;
External IDs OMIM602115 MGI1099809 HomoloGene3284 GeneCards: FGF10 Gene
Species Human Mouse
Entrez 2255 14165
Ensembl ENSG00000070193 ENSMUSG00000021732
UniProt O15520 Q76LY2
RefSeq (mRNA) NM_004465 NM_008002
RefSeq (protein) NP_004456 NP_032028
Location (UCSC) Chr 5:
44.34 - 44.42 Mb
Chr 13:
119.83 - 119.91 Mb
PubMed search [1] [2]

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.[2]


  1. ^ Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (Oct 1997). "Structure and expression of human fibroblast growth factor-10". J Biol Chem 272 (37): 23191-4. PMID 9287324.  
  2. ^ a b "Entrez Gene: FGF10 fibroblast growth factor 10".  

Further reading

  • Igarashi M, Finch PW, Aaronson SA (1998). "Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7).". J. Biol. Chem. 273 (21): 13230–5. PMID 9582367.  
  • Sekine K, Ohuchi H, Fujiwara M, et al. (1999). "Fgf10 is essential for limb and lung formation.". Nat. Genet. 21 (1): 138–41. doi:10.1038/5096. PMID 9916808.  
  • Jimenez PA, Rampy MA (1999). "Keratinocyte growth factor-2 accelerates wound healing in incisional wounds.". J. Surg. Res. 81 (2): 238–42. doi:10.1006/jsre.1998.5501. PMID 9927546.  
  • Ropiquet F, Giri D, Kwabi-Addo B, et al. (2000). "FGF-10 is expressed at low levels in the human prostate.". Prostate 44 (4): 334–8. PMID 10951499.  
  • Marchese C, Felici A, Visco V, et al. (2001). "Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes.". J. Invest. Dermatol. 116 (4): 623–8. doi:10.1046/j.0022-202x.2001.01280.x. PMID 11286634.  
  • Bagai S, Rubio E, Cheng JF, et al. (2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells.". J. Biol. Chem. 277 (26): 23828–37. doi:10.1074/jbc.M201658200. PMID 11923311.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Yeh BK, Igarashi M, Eliseenkova AV, et al. (2003). "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2266–71. doi:10.1073/pnas.0436500100. PMID 12591959.  
  • Upadhyay D, Lecuona E, Comellas A, et al. (2003). "Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway.". FEBS Lett. 545 (2-3): 173–6. PMID 12804770.  
  • Izvolsky KI, Zhong L, Wei L, et al. (2003). "Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (4): L838–46. doi:10.1152/ajplung.00081.2003. PMID 12818887.  
  • Tomlinson DC, Grindley JC, Thomson AA (2004). "Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements.". Endocrinology 145 (4): 1988–95. doi:10.1210/en.2003-0842. PMID 14726452.  
  • Upadhyay D, Bundesmann M, Panduri V, et al. (2004). "Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair.". Am. J. Respir. Cell Mol. Biol. 31 (1): 107–13. doi:10.1165/rcmb.2003-0064OC. PMID 14975937.  
  • Theodorou V, Boer M, Weigelt B, et al. (2005). "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas.". Oncogene 23 (36): 6047–55. doi:10.1038/sj.onc.1207816. PMID 15208658.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ibrahimi OA, Yeh BK, Eliseenkova AV, et al. (2005). "Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization.". Mol. Cell. Biol. 25 (2): 671–84. doi:10.1128/MCB.25.2.671-684.2005. PMID 15632068.  
  • Entesarian M, Matsson H, Klar J, et al. (2005). "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.". Nat. Genet. 37 (2): 125–7. doi:10.1038/ng1507. PMID 15654336.  
  • Kovacs D, Falchi M, Cardinali G, et al. (2005). "Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis.". Exp. Dermatol. 14 (2): 130–7. doi:10.1111/j.0906-6705.2005.00261.x. PMID 15679583.  
  • Ye F, Duvillié B, Scharfmann R (2005). "Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.". Diabetologia 48 (2): 277–81. doi:10.1007/s00125-004-1638-6. PMID 15690149.  
  • Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.". Oncogene 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171.  


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