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Fibroblast growth factor 12

PDB rendering based on 1q1u.
Available structures
Symbols FGF12; FGF12B; FHF1
External IDs OMIM601513 MGI109183 HomoloGene10874 GeneCards: FGF12 Gene
RNA expression pattern
PBB GE FGF12 207501 s at tn.png
PBB GE FGF12 214589 at tn.png
More reference expression data
Species Human Mouse
Entrez 2257 14167
Ensembl ENSG00000114279 ENSMUSG00000022523
UniProt P61328 O35340
RefSeq (mRNA) NM_004113 NM_010199
RefSeq (protein) NP_004104 NP_034329
Location (UCSC) Chr 3:
193.34 - 193.61 Mb
Chr 16:
28.08 - 28.48 Mb
PubMed search [1] [2]

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.[1][2][3]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]


  1. ^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A 93 (18): 9850-7. PMID 8790420.  
  2. ^ Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet 78 (1): 48-9. PMID 9345906.  
  3. ^ a b "Entrez Gene: FGF12 fibroblast growth factor 12".  

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.  
  • Kok LD, Tsui SK, Waye M, et al. (1999). "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart.". Biochem. Biophys. Res. Commun. 255 (3): 717–21. doi:10.1006/bbrc.1999.0178. PMID 10049777.  
  • Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins.". Curr. Biol. 11 (10): 793–7. doi:10.1016/S0960-9822(01)00232-9. PMID 11378392.  
  • Liu CJ, Dib-Hajj SD, Renganathan M, et al. (2003). "Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B.". J. Biol. Chem. 278 (2): 1029–36. doi:10.1074/jbc.M207074200. PMID 12401812.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Olsen SK, Garbi M, Zampieri N, et al. (2003). "Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.". J. Biol. Chem. 278 (36): 34226–36. doi:10.1074/jbc.M303183200. PMID 12815063.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9.". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


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