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Fibroblast growth factor 6
Identifiers
Symbols FGF6; HBGF-6; HST2
External IDs OMIM134921 MGI95520 HomoloGene10870 GeneCards: FGF6 Gene
RNA expression pattern
PBB GE FGF6 208417 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2251 14177
Ensembl ENSG00000111241 ENSMUSG00000000183
UniProt P10767 Q8C399
RefSeq (mRNA) NM_020996 XM_001003439
RefSeq (protein) NP_066276 XP_001003439
Location (UCSC) Chr 12:
4.41 - 4.43 Mb
Chr 6:
126.98 - 126.99 Mb
PubMed search [1] [2]

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.[2]

References

Further reading

  • Vainikka S, Partanen J, Bellosta P, et al. (1992). "Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.". Embo J. 11 (12): 4273–80. PMID 1385111.  
  • Iida S, Yoshida T, Naito K, et al. (1992). "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization.". Oncogene 7 (2): 303–9. PMID 1549352.  
  • Coulier F, Batoz M, Marics I, et al. (1991). "Putative structure of the FGF6 gene product and role of the signal peptide.". Oncogene 6 (8): 1437–44. PMID 1886714.  
  • Marics I, Adelaide J, Raybaud F, et al. (1989). "Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.". Oncogene 4 (3): 335–40. PMID 2649847.  
  • Aerssens J, Chaffanet M, Baens M, et al. (1994). "Regional assignment of seven loci to 12p13.2-pter by PCR analysis of somatic cell hybrids containing the der(12) or the der(X) chromosome from a mesothelioma showing t(X;12)(q22;p13).". Genomics 20 (1): 119–21. doi:10.1006/geno.1994.1136. PMID 8020938.  
  • Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family.". J. Biol. Chem. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044.  
  • Ropiquet F, Giri D, Kwabi-Addo B, et al. (2000). "Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer.". Cancer Res. 60 (15): 4245–50. PMID 10945637.  
  • Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant.". Clin. Cancer Res. 8 (1): 246–57. PMID 11801566.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9.". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
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