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Four and a half LIM domains 5

PDB rendering based on 1x68.
Available structures
Symbols FHL5; ACT; FLJ33049; KIAA0776; RP3-393D12.2; dJ393D12.2
External IDs OMIM605126 MGI1913192 HomoloGene23230 GeneCards: FHL5 Gene
RNA expression pattern
PBB GE FHL5 220170 at tn.png
More reference expression data
Species Human Mouse
Entrez 9457 57756
Ensembl ENSG00000112214 ENSMUSG00000028259
UniProt Q5TD97 Q9WTX7
RefSeq (mRNA) NM_020482 NM_021318
RefSeq (protein) NP_065228 NP_067293
Location (UCSC) Chr 6:
97.12 - 97.17 Mb
Chr 4:
25.29 - 25.33 Mb
PubMed search [1] [2]

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.[1]

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.[1]



FHL5 has been shown to interact with CREB1[2] and CAMP responsive element modulator.[2][3]


  1. ^ a b "Entrez Gene: FHL5 four and a half LIM domains 5".  
  2. ^ a b Fimia, G M; De Cesare D, Sassone-Corsi P (Nov. 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22. ISSN 0270-7306. PMID 11046156.  
  3. ^ Fimia, G M; De Cesare D, Sassone-Corsi P (Mar. 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature (ENGLAND) 398 (6723): 165–9. doi:10.1038/18237. ISSN 0028-0836. PMID 10086359.  

Further reading

  • Fimia GM, Morlon A, Macho B, et al. (2001). "Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT.". Mol. Cell. Endocrinol. 179 (1-2): 17–23. doi:10.1016/S0303-7207(01)00463-4. PMID 11420126.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Fimia GM, De Cesare D, Sassone-Corsi P (1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT.". Nature 398 (6723): 165–9. doi:10.1038/18237. PMID 10086359.  
  • Fimia GM, De Cesare D, Sassone-Corsi P (2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM.". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMID 11046156.  
  • Palermo I, Litrico L, Emmanuele G, et al. (2001). "Cloning and expression of activator of CREM in testis in human testicular tissue.". Biochem. Biophys. Res. Commun. 283 (2): 406–11. doi:10.1006/bbrc.2001.4805. PMID 11327716.  
  • Peri A, Luciani P, Tonacchera M, et al. (2002). "Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas.". Eur. J. Endocrinol. 146 (6): 759–66. doi:10.1530/eje.0.1460759. PMID 12039695.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Macho B, Brancorsini S, Fimia GM, et al. (2003). "CREM-dependent transcription in male germ cells controlled by a kinesin.". Science 298 (5602): 2388–90. doi:10.1126/science.1077265. PMID 12493914.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Philippar U, Schratt G, Dieterich C, et al. (2005). "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF.". Mol. Cell 16 (6): 867–80. doi:10.1016/j.molcel.2004.11.039. PMID 15610731.  
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Christensen GL, Wooding SP, Ivanov IP, et al. (2006). "Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males.". Mol. Hum. Reprod. 12 (4): 257–62. doi:10.1093/molehr/gal006. PMID 16687568.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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