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FOS-like antigen 1
Symbols FOSL1; FRA1; fra-1
External IDs OMIM136515 MGI107179 HomoloGene3967 GeneCards: FOSL1 Gene
RNA expression pattern
PBB GE FOSL1 204420 at tn.png
PBB GE FOSL1 213250 at tn.png
More reference expression data
Species Human Mouse
Entrez 8061 14283
Ensembl ENSG00000175592 ENSMUSG00000024912
UniProt P15407 Q3UMA0
RefSeq (mRNA) NM_005438 NM_010235
RefSeq (protein) NP_005429 NP_034365
Location (UCSC) Chr 11:
65.42 - 65.42 Mb
Chr 19:
5.45 - 5.46 Mb
PubMed search [1] [2]

Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene.[1][2]

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[2]



FOSL1 has been shown to interact with USF1 (human gene)[3] and C-jun.[3]

See also


  1. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Apr 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene 5 (3): 249–55. PMID 2107490.  
  2. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1".  
  3. ^ a b Pognonec, P; Boulukos K E, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May. 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene (ENGLAND) 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. ISSN 0950-9232. PMID 9160889.  

Further reading

  • Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.". Brain Res. Brain Res. Rev. 28 (3): 370–490. doi:10.1016/S0165-0173(98)00018-6. PMID 9858769.  
  • Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L1161–78. doi:10.1152/ajplung.00140.2002. PMID 12424143.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Tsuchiya H, Fujii M, Niki T, et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals.". J. Virol. 67 (12): 7001–7. PMID 8230424.  
  • Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13.". Genomics 18 (1): 165. doi:10.1006/geno.1993.1447. PMID 8276409.  
  • Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1).". Genomics 37 (3): 354–65. PMID 8938448.  
  • Arts J, Herr I, Lansink M, et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro.". Nucleic Acids Res. 25 (2): 311–7. doi:10.1093/nar/25.2.311. PMID 9016559.  
  • Pognonec P, Boulukos KE, Aperlo C, et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity.". Oncogene 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.  
  • Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13.". Genome Res. 7 (8): 835–42. PMID 9267807.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Puntschart A, Wey E, Jostarndt K, et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise.". Am. J. Physiol. 274 (1 Pt 1): C129–37. PMID 9458721.  
  • Finzer P, Soto U, Delius H, et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.". Oncogene 19 (29): 3235–44. doi:10.1038/sj.onc.1203643. PMID 10918580.  
  • Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771.  
  • Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197.  
  • Wang HL, Wang J, Xiao SY, et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.". Int. J. Cancer 101 (4): 301–10. doi:10.1002/ijc.10630. PMID 12209953.  
  • Bergman MR, Cheng S, Honbo N, et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.". Biochem. J. 369 (Pt 3): 485–96. doi:10.1042/BJ20020707. PMID 12371906.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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