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FOS-like antigen 2
Symbols FOSL2; FLJ23306; FRA2
External IDs OMIM601575 MGI102858 HomoloGene3845 GeneCards: FOSL2 Gene
RNA expression pattern
PBB GE FOSL2 205409 at tn.png
PBB GE FOSL2 218880 at tn.png
PBB GE FOSL2 218881 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2355 14284
Ensembl ENSG00000075426 n/a
UniProt P15408 n/a
RefSeq (mRNA) NM_005253 NM_008037
RefSeq (protein) NP_005244 NP_032063
Location (UCSC) Chr 2:
28.47 - 28.49 Mb
PubMed search [1] [2]

Fos-related antigen 2 is a protein that in humans is encoded by the FOSL2 gene.[1]

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[1]


See also


Further reading

  • Matsui M, Tokuhara M, Konuma Y, et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.". Oncogene 5 (3): 249–55. PMID 2107490.  
  • Molven A, Houge G, Berger R (1997). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23.". Genomics 38 (1): 72–5. doi:10.1006/geno.1996.0593. PMID 8954781.  
  • Outinen PA, Sood SK, Pfeifer SI, et al. (1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells.". Blood 94 (3): 959–67. PMID 10419887.  
  • Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367.  
  • Ng DC, Shafaee S, Lee D, Bikle DD (2000). "Requirement of an AP-1 site in the calcium response region of the involucrin promoter.". J. Biol. Chem. 275 (31): 24080–8. doi:10.1074/jbc.M002508200. PMID 10816578.  
  • Bamberger AM, Milde-Langosch K, Rössing E, et al. (2001). "Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators.". J. Cancer Res. Clin. Oncol. 127 (9): 545–50. doi:10.1007/s004320100255. PMID 11570575.  
  • Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771.  
  • Benkoussa M, Brand C, Delmotte MH, et al. (2002). "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.". Mol. Cell. Biol. 22 (13): 4522–34. doi:10.1128/MCB.22.13.4522-4534.2002. PMID 12052862.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Santalucía T, Christmann M, Yacoub MH, Brand NJ (2004). "Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1.". Cardiovasc. Res. 59 (3): 639–48. doi:10.1016/S0008-6363(03)00472-3. PMID 14499865.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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