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FOXC2: Wikis

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forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Identifiers
Symbol FOXC2
Alt. symbols FKHL14
Entrez 2303
HUGO 3801
OMIM 602402
RefSeq NM_005251
UniProt Q99958
Other data
Locus Chr. 16 q22-16q24

FOXC2 is a gene associated with lymphedema distichiasis, and that has been studied to determine if it is associated with varicose veins.

FOXC2 is also involved in cancer metastases. Particularly, expression of FOXC2 is induced when epithelial cells undergo an epithelial-mesenchymal transition (EMT) and become mesenchymal looking cells. EMT can be induced by a number of genes including Snail, Twist, Goosecoid, and TGF-beta 1. Suppression of FOXC2 expression using shRNA in a highly metastatic breast cancer model blocks their metastatic ability.

Further reading

  • Ng M, Andrew T, Spector T, Jeffery S (2005). "Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs.". J Med Genet 42 (3): 235–9. doi:10.1136/jmg.2004.024075. PMID 15744037.  
  • Sendurai A. Mani, Jing Yang, Mary Brooks, Gunda Schwaninger, Alicia Zhou, Naoyuki Miura, Jeffery L. Kutok, Kimberly Hartwell, Andrea L. Richardson, and Robert A. Weinberg (2007). "Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers.". Proceedings of the National Academy of Sciences 104 (24): 10069–74. doi:10.1073/pnas.0703900104. PMID 17537911.  
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