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Forkhead box F1
Identifiers
Symbols FOXF1; FKHL5; FREAC1; MGC105125
External IDs OMIM601089 MGI1347470 HomoloGene1114 GeneCards: FOXF1 Gene
RNA expression pattern
PBB GE FOXF1 205935 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2294 15227
Ensembl ENSG00000103241 ENSMUSG00000042812
UniProt Q12946 Q61080
RefSeq (mRNA) NM_001451 NM_010426
RefSeq (protein) NP_001442 NP_034556
Location (UCSC) Chr 16:
85.1 - 85.11 Mb
Chr 8:
123.97 - 123.97 Mb
PubMed search [1] [2]

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.[1][2][3]

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.[3]

References

  1. ^ Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P (Feb 1997). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics 30 (3): 464-9. doi:10.1006/geno.1995.1266. PMID 8825632.  
  2. ^ Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P (Dec 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J 13 (20): 5002-12. PMID 7957066.  
  3. ^ a b "Entrez Gene: FOXF1 forkhead box F1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2294.  

Further reading

  • Murphy DB, Wiese S, Burfeind P, et al. (1994). "Human brain factor 1, a new member of the fork head gene family.". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.  
  • Hellqvist M, Mahlapuu M, Samuelsson L, et al. (1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.". J. Biol. Chem. 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802.  
  • Hellqvist M, Mahlapuu M, Blixt A, et al. (1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.". J. Biol. Chem. 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567.  
  • Mahlapuu M, Pelto-Huikko M, Aitola M, et al. (1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces.". Dev. Biol. 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Coon DR, Roberts DJ, Loscertales M, Kradin R (2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia.". Exp. Mol. Pathol. 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649.  
  • Lomenick JP, Hubert MA, Handwerger S (2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression.". Am. J. Physiol. Endocrinol. Metab. 291 (5): E947–51. doi:10.1152/ajpendo.00128.2006. PMID 16772323.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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