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Forkhead box F1
Symbols FOXF1; FKHL5; FREAC1; MGC105125
External IDs OMIM601089 MGI1347470 HomoloGene1114 GeneCards: FOXF1 Gene
RNA expression pattern
PBB GE FOXF1 205935 at tn.png
More reference expression data
Species Human Mouse
Entrez 2294 15227
Ensembl ENSG00000103241 ENSMUSG00000042812
UniProt Q12946 Q61080
RefSeq (mRNA) NM_001451 NM_010426
RefSeq (protein) NP_001442 NP_034556
Location (UCSC) Chr 16:
85.1 - 85.11 Mb
Chr 8:
123.97 - 123.97 Mb
PubMed search [1] [2]

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.[1][2][3]

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.[3]


  1. ^ Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P (Feb 1997). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics 30 (3): 464-9. doi:10.1006/geno.1995.1266. PMID 8825632.  
  2. ^ Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P (Dec 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J 13 (20): 5002-12. PMID 7957066.  
  3. ^ a b "Entrez Gene: FOXF1 forkhead box F1".  

Further reading

  • Murphy DB, Wiese S, Burfeind P, et al. (1994). "Human brain factor 1, a new member of the fork head gene family.". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.  
  • Hellqvist M, Mahlapuu M, Samuelsson L, et al. (1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.". J. Biol. Chem. 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802.  
  • Hellqvist M, Mahlapuu M, Blixt A, et al. (1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.". J. Biol. Chem. 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567.  
  • Mahlapuu M, Pelto-Huikko M, Aitola M, et al. (1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces.". Dev. Biol. 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Coon DR, Roberts DJ, Loscertales M, Kradin R (2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia.". Exp. Mol. Pathol. 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649.  
  • Lomenick JP, Hubert MA, Handwerger S (2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression.". Am. J. Physiol. Endocrinol. Metab. 291 (5): E947–51. doi:10.1152/ajpendo.00128.2006. PMID 16772323.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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