The Full Wiki

FOXG1: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Forkhead box G1B
Symbols FOXG1B; BF1; FKH2; FKHL1; FKHL4; HBF-1; HFK1; QIN
External IDs OMIM164874 MGI1347464 HomoloGene3843 GeneCards: FOXG1B Gene
RNA expression pattern
PBB GE FOXG1B 206018 at tn.png
PBB GE FOXG1B 207658 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2290 15228
Ensembl ENSG00000176165 ENSMUSG00000020950
UniProt P55315 Q3V1Q8
RefSeq (mRNA) NM_005249 XM_992309
RefSeq (protein) NP_005240 XP_997403
Location (UCSC) Chr 14:
28.3 - 28.31 Mb
Chr 12:
50.26 - 50.27 Mb
PubMed search [1] [2]

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.[1][2][3]

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.[3]


See also


FOXG1 has been shown to interact with JARID1B.[4]


  1. ^ Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Nov 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.  
  2. ^ Bredenkamp N, Seoighe C, Illing N (Feb 2007). "Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation". Dev Genes Evol 217 (3): 227–33. doi:10.1007/s00427-006-0128-x. PMID 17260156.  
  3. ^ a b "Entrez Gene: FOXG1B forkhead box G1B".  
  4. ^ Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten, Taylor-Papadimitriou Joyce, Freemont Paul S (Jun. 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. (United States) 278 (23): 20507–13. doi:10.1074/jbc.M301994200. ISSN 0021-9258. PMID 12657635.  

Further reading

  • Li J, Chang HW, Lai E, et al. (1995). "The oncogene qin codes for a transcriptional repressor.". Cancer Res. 55 (23): 5540–4. PMID 7585630.  
  • Wiese S, Murphy DB, Schlung A, et al. (1995). "The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.". Biochim. Biophys. Acta 1262 (2-3): 105–12. PMID 7599184.  
  • Pierrou S, Hellqvist M, Samuelsson L, et al. (1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.". EMBO J. 13 (20): 5002–12. PMID 7957066.  
  • Li J, Vogt PK (1993). "The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head.". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4490–4. doi:10.1073/pnas.90.10.4490. PMID 8099441.  
  • Kastury K, Li J, Druck T, et al. (1994). "The human homologue of the retroviral oncogene qin maps to chromosome 14q13.". Proc. Natl. Acad. Sci. U.S.A. 91 (9): 3616–8. doi:10.1073/pnas.91.9.3616. PMID 8170957.  
  • Huh S, Hatini V, Marcus RC, et al. (1999). "Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression.". Dev. Biol. 211 (1): 53–63. doi:10.1006/dbio.1999.9303. PMID 10373304.  
  • Dou CL, Li S, Lai E (1999). "Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres.". Cereb. Cortex 9 (6): 543–50. doi:10.1093/cercor/9.6.543. PMID 10498272.  
  • Dou C, Lee J, Liu B, et al. (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMID 10938097.  
  • Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMID 11238932.  
  • Rodriguez C, Huang LJ, Son JK, et al. (2001). "Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.". J. Biol. Chem. 276 (32): 30224–30. doi:10.1074/jbc.M102759200. PMID 11387330.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.  
  • Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635.  
  • Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.". Cell 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259.  
  • Shoichet SA, Kunde SA, Viertel P, et al. (2005). "Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly.". Hum. Genet. 117 (6): 536–44. doi:10.1007/s00439-005-1310-3. PMID 16133170.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address