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Forkhead box G1B
Identifiers
Symbols FOXG1B; BF1; FKH2; FKHL1; FKHL4; HBF-1; HFK1; QIN
External IDs OMIM164874 MGI1347464 HomoloGene3843 GeneCards: FOXG1B Gene
RNA expression pattern
PBB GE FOXG1B 206018 at tn.png
PBB GE FOXG1B 207658 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2290 15228
Ensembl ENSG00000176165 ENSMUSG00000020950
UniProt P55315 Q3V1Q8
RefSeq (mRNA) NM_005249 XM_992309
RefSeq (protein) NP_005240 XP_997403
Location (UCSC) Chr 14:
28.3 - 28.31 Mb
Chr 12:
50.26 - 50.27 Mb
PubMed search [1] [2]

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.[1][2][3]

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.[3]

Contents

See also

Interactions

FOXG1 has been shown to interact with JARID1B.[4]

References

  1. ^ Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Nov 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.  
  2. ^ Bredenkamp N, Seoighe C, Illing N (Feb 2007). "Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation". Dev Genes Evol 217 (3): 227–33. doi:10.1007/s00427-006-0128-x. PMID 17260156.  
  3. ^ a b "Entrez Gene: FOXG1B forkhead box G1B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2290.  
  4. ^ Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten, Taylor-Papadimitriou Joyce, Freemont Paul S (Jun. 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. (United States) 278 (23): 20507–13. doi:10.1074/jbc.M301994200. ISSN 0021-9258. PMID 12657635.  

Further reading

  • Li J, Chang HW, Lai E, et al. (1995). "The oncogene qin codes for a transcriptional repressor.". Cancer Res. 55 (23): 5540–4. PMID 7585630.  
  • Wiese S, Murphy DB, Schlung A, et al. (1995). "The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.". Biochim. Biophys. Acta 1262 (2-3): 105–12. PMID 7599184.  
  • Pierrou S, Hellqvist M, Samuelsson L, et al. (1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.". EMBO J. 13 (20): 5002–12. PMID 7957066.  
  • Li J, Vogt PK (1993). "The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head.". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4490–4. doi:10.1073/pnas.90.10.4490. PMID 8099441.  
  • Kastury K, Li J, Druck T, et al. (1994). "The human homologue of the retroviral oncogene qin maps to chromosome 14q13.". Proc. Natl. Acad. Sci. U.S.A. 91 (9): 3616–8. doi:10.1073/pnas.91.9.3616. PMID 8170957.  
  • Huh S, Hatini V, Marcus RC, et al. (1999). "Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression.". Dev. Biol. 211 (1): 53–63. doi:10.1006/dbio.1999.9303. PMID 10373304.  
  • Dou CL, Li S, Lai E (1999). "Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres.". Cereb. Cortex 9 (6): 543–50. doi:10.1093/cercor/9.6.543. PMID 10498272.  
  • Dou C, Lee J, Liu B, et al. (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMID 10938097.  
  • Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMID 11238932.  
  • Rodriguez C, Huang LJ, Son JK, et al. (2001). "Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.". J. Biol. Chem. 276 (32): 30224–30. doi:10.1074/jbc.M102759200. PMID 11387330.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.  
  • Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635.  
  • Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.". Cell 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259.  
  • Shoichet SA, Kunde SA, Viertel P, et al. (2005). "Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly.". Hum. Genet. 117 (6): 536–44. doi:10.1007/s00439-005-1310-3. PMID 16133170.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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