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Forkhead box H1
Identifiers
Symbols FOXH1; FAST-1; FAST1
External IDs OMIM603621 MGI1347465 HomoloGene2914 GeneCards: FOXH1 Gene
RNA expression pattern
PBB GE FOXH1 207644 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8928 14106
Ensembl ENSG00000160973 ENSMUSG00000033837
UniProt O75593 Q0VEP8
RefSeq (mRNA) NM_003923 NM_007989
RefSeq (protein) NP_003914 NP_032015
Location (UCSC) Chr 8:
145.67 - 145.67 Mb
Chr 15:
76.5 - 76.5 Mb
PubMed search [1] [2]

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]

Contents

See also

Interactions

FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

References

  1. ^ Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (Aug 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell 2 (1): 121–7. PMID 9702198.  
  2. ^ a b "Entrez Gene: FOXH1 forkhead box H1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928.  
  3. ^ Iratni, Rabah; Yan Yu-Ting, Chen Canhe, Ding Jixiang, Zhang Yi, Price Sandy M, Reinberg Danny, Shen Michael M (Dec. 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science (United States) 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.  
  4. ^ Wotton, D; Lo R S, Lee S, Massagué J (Apr. 1999). "A Smad transcriptional corepressor". Cell (UNITED STATES) 97 (1): 29–39. ISSN 0092-8674. PMID 10199400.  
  5. ^ Liu, B; Dou C L, Prabhu L, Lai E (Jan. 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. (UNITED STATES) 19 (1): 424–30. ISSN 0270-7306. PMID 9858566.  
  6. ^ Liu, F; Pouponnot C, Massagué J (Dec. 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. (UNITED STATES) 11 (23): 3157–67. ISSN 0890-9369. PMID 9389648.  
  7. ^ Dou, C; Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (Sep. 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6201–11. ISSN 0270-7306. PMID 10938097.  
  8. ^ Chen, X; Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (Sep. 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature (ENGLAND) 389 (6646): 85–9. doi:10.1038/38008. ISSN 0028-0836. PMID 9288972.  

Further reading

  • Chen X, Weisberg E, Fridmacher V, et al. (1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor.". Nature 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.  
  • Liu F, Pouponnot C, Massagué J (1998). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMID 9389648.  
  • Liu B, Dou CL, Prabhu L, Lai E (1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.". Mol. Cell. Biol. 19 (1): 424–30. PMID 9858566.  
  • Dou C, Lee J, Liu B, et al. (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMID 10938097.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Pessah M, Prunier C, Marais J, et al. (2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198–203. doi:10.1073/pnas.101579798. PMID 11371641.  
  • Iratni R, Yan YT, Chen C, et al. (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.". Science 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.". Cell 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259.  
  • von Both I, Silvestri C, Erdemir T, et al. (2004). "Foxh1 is essential for development of the anterior heart field.". Dev. Cell 7 (3): 331–45. doi:10.1016/j.devcel.2004.07.023. PMID 15363409.  
  • Kelemen SF, Eisen HJ, Autieri MV (2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells.". J. Heart Lung Transplant. 24 (3): 246–50. doi:10.1016/j.healun.2004.01.015. PMID 15737749.  
  • Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.". Oncogene 24 (24): 3864–74. doi:10.1038/sj.onc.1208556. PMID 15750622.  
  • Hart AH, Willson TA, Wong M, et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.  
  • Chen G, Nomura M, Morinaga H, et al. (2006). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.". J. Biol. Chem. 280 (43): 36355–63. doi:10.1074/jbc.M506147200. PMID 16120611.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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